Epigenetic silencing of microRNA-373 to epithelial-mesenchymal transition in non-small cell lung cancer through IRAK2 and LAMP1 axes

Highlights • miR-373 identified as a target of epigenetic aberration in NSCLC. • miR-373 acts as a tumor suppressor. • miR-33 is a negative regulator of the EMT in lung cancer. • miR-373 regulates EMT phenotype through IRAK2 and LAMP1.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2014-10, Vol.353 (2), p.232-241
Hauptverfasser:	Seol, Hyang Sook, Akiyama, Yoshimitsu, Shimada, Shu, Lee, Hee Jin, Kim, Tae Im, Chun, Sung Min, Singh, Shree Ram, Jang, Se Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Cell growth Cell Line, Tumor Confidence intervals Deoxyribonucleic acid Disease-Free Survival DNA DNA methylation Epigenesis, Genetic Epigenetics Epithelial-Mesenchymal Transition Female Gene expression Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Histone deacetylase Histones - metabolism Humans Interleukin-1 Receptor-Associated Kinases - metabolism IRAK2 Kaplan-Meier Estimate Kinases LAMP1 Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Lysosomal Membrane Proteins - metabolism Male Metastasis microRNA-373 MicroRNAs MicroRNAs - metabolism Mortality Multivariate Analysis Non-small cell lung cancer Proportional Hazards Models Protein Processing, Post-Translational Survival analysis Tumor suppressor
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Beschreibung
Zusammenfassung:	Highlights • miR-373 identified as a target of epigenetic aberration in NSCLC. • miR-373 acts as a tumor suppressor. • miR-33 is a negative regulator of the EMT in lung cancer. • miR-373 regulates EMT phenotype through IRAK2 and LAMP1.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.07.019