Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection
In patients coinfected with SARS-CoV-2 and HBV, liver injury was common. However, the interactions between SARS-CoV-2 and HBV coinfection remained unknown. Sixty-seven COVID-19 patients from the previous cohort were enrolled and classified into 2 groups (7 with HBsAg+ and 60 with HBsAg-). The associ...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 2021-01, Vol.553, p.131-134 |
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| creator | Yu, Rentao Tan, Shun Dan, Yunjie Lu, Yanqiu Zhang, Juan Tan, Zhaoxia He, Xiaoqing Xiang, Xiaomei Zhou, Yi Guo, Yanzhi Deng, Guohong Chen, Yaokai Tan, Wenting |
| description | In patients coinfected with SARS-CoV-2 and HBV, liver injury was common. However, the interactions between SARS-CoV-2 and HBV coinfection remained unknown. Sixty-seven COVID-19 patients from the previous cohort were enrolled and classified into 2 groups (7 with HBsAg+ and 60 with HBsAg-). The association of HBV- and SARS-CoV-2-related markers were analyzed. During the acute course of SARS-CoV-2 infection, markers of HBV replication did not extensively fluctuate during SARS-CoV-2 infection. Coinfection with HBV did not extend the viral shedding cycle or incubation periods of SARS-CoV-2. Effects of SARS-CoV-2 on the dynamics of chronic HBV infection seemed not apparent. SARS-CoV-2 infection would not be the source of HBV reactivation in these individuals.
•The direct interactions between SARS-CoV-2 and HBV coinfection is important in clinics.•Effects of SARS-CoV-2 on the dynamics of chronic HBV infection seemed not apparent.•SARS-CoV-2 infection would not be the source of HBV reactivation.•Coinfection of HBV did not increase the severity of diseases or duration of hospitalization. |
| doi_str_mv | 10.1016/j.virol.2020.11.012 |
| format | Article |
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•The direct interactions between SARS-CoV-2 and HBV coinfection is important in clinics.•Effects of SARS-CoV-2 on the dynamics of chronic HBV infection seemed not apparent.•SARS-CoV-2 infection would not be the source of HBV reactivation.•Coinfection of HBV did not increase the severity of diseases or duration of hospitalization.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1016/j.virol.2020.11.012</identifier><identifier>PMID: 33276282</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Chronic hepatitis B ; Coinfection - drug therapy ; Coinfection - virology ; COVID-19 ; COVID-19 - drug therapy ; COVID-19 - virology ; Female ; HBV ; Hepatitis B, Chronic - drug therapy ; Hepatitis B, Chronic - virology ; Humans ; Liver injury ; Male ; Middle Aged ; SARS-CoV-2 ; Virus Activation ; Virus Shedding</subject><ispartof>Virology (New York, N.Y.), 2021-01, Vol.553, p.131-134</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020. Published by Elsevier Inc.</rights><rights>2020 Elsevier Inc. 2020 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-d9359cf775d3c2f686679b862665123c40ca63fa17f0dcfb8b483b8cfdcf7b1d3</citedby><cites>FETCH-LOGICAL-c459t-d9359cf775d3c2f686679b862665123c40ca63fa17f0dcfb8b483b8cfdcf7b1d3</cites><orcidid>0000-0002-3229-0108 ; 0000-0003-4952-9274</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.virol.2020.11.012$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33276282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Rentao</creatorcontrib><creatorcontrib>Tan, Shun</creatorcontrib><creatorcontrib>Dan, Yunjie</creatorcontrib><creatorcontrib>Lu, Yanqiu</creatorcontrib><creatorcontrib>Zhang, Juan</creatorcontrib><creatorcontrib>Tan, Zhaoxia</creatorcontrib><creatorcontrib>He, Xiaoqing</creatorcontrib><creatorcontrib>Xiang, Xiaomei</creatorcontrib><creatorcontrib>Zhou, Yi</creatorcontrib><creatorcontrib>Guo, Yanzhi</creatorcontrib><creatorcontrib>Deng, Guohong</creatorcontrib><creatorcontrib>Chen, Yaokai</creatorcontrib><creatorcontrib>Tan, Wenting</creatorcontrib><title>Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection</title><title>Virology (New York, N.Y.)</title><addtitle>Virology</addtitle><description>In patients coinfected with SARS-CoV-2 and HBV, liver injury was common. However, the interactions between SARS-CoV-2 and HBV coinfection remained unknown. Sixty-seven COVID-19 patients from the previous cohort were enrolled and classified into 2 groups (7 with HBsAg+ and 60 with HBsAg-). The association of HBV- and SARS-CoV-2-related markers were analyzed. During the acute course of SARS-CoV-2 infection, markers of HBV replication did not extensively fluctuate during SARS-CoV-2 infection. Coinfection with HBV did not extend the viral shedding cycle or incubation periods of SARS-CoV-2. Effects of SARS-CoV-2 on the dynamics of chronic HBV infection seemed not apparent. SARS-CoV-2 infection would not be the source of HBV reactivation in these individuals.
•The direct interactions between SARS-CoV-2 and HBV coinfection is important in clinics.•Effects of SARS-CoV-2 on the dynamics of chronic HBV infection seemed not apparent.•SARS-CoV-2 infection would not be the source of HBV reactivation.•Coinfection of HBV did not increase the severity of diseases or duration of hospitalization.</description><subject>Adult</subject><subject>Aged</subject><subject>Chronic hepatitis B</subject><subject>Coinfection - drug therapy</subject><subject>Coinfection - virology</subject><subject>COVID-19</subject><subject>COVID-19 - drug therapy</subject><subject>COVID-19 - virology</subject><subject>Female</subject><subject>HBV</subject><subject>Hepatitis B, Chronic - drug therapy</subject><subject>Hepatitis B, Chronic - virology</subject><subject>Humans</subject><subject>Liver injury</subject><subject>Male</subject><subject>Middle Aged</subject><subject>SARS-CoV-2</subject><subject>Virus Activation</subject><subject>Virus Shedding</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1KAzEQhYMotlafQJC8wNb87Ca7Fwq11B8oCFa9DdlsYlPaZEnWSt_e1GrRG6-GmZxzJvMBcI7RECPMLhfDtQ1-OSSIpAkeIkwOQB-jimWI5vgQ9BHKScZKQnrgJMYFSj3n6Bj0KCWckZL0QT0xRqsOegNno6dZNvavGYHKW7cdW-_gh4zQ-Q7KtpVBuyR1sJtr2GycXFkVt1Y1D95ZBee6lZ3tbIQ3cJ9wCo6MXEZ99l0H4OV28jy-z6aPdw_j0TRTeVF1WVPRolKG86KhihhWMsarumSEsQITqnKkJKNGYm5Qo0xd1nlJ61KZ1PAaN3QArne57Xu90o1Kfw1yKdpgVzJshJdW_H1xdi7e_FpwVpWsYCmA7gJU8DEGbfZejMQWuViIL-Rii1xgLBLy5Lr4vXbv-WGcBFc7gU7Hr60OIiqrndKNDYmQaLz9d8EnFqSVdA</recordid><startdate>20210115</startdate><enddate>20210115</enddate><creator>Yu, Rentao</creator><creator>Tan, Shun</creator><creator>Dan, Yunjie</creator><creator>Lu, Yanqiu</creator><creator>Zhang, Juan</creator><creator>Tan, Zhaoxia</creator><creator>He, Xiaoqing</creator><creator>Xiang, Xiaomei</creator><creator>Zhou, Yi</creator><creator>Guo, Yanzhi</creator><creator>Deng, Guohong</creator><creator>Chen, Yaokai</creator><creator>Tan, Wenting</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3229-0108</orcidid><orcidid>https://orcid.org/0000-0003-4952-9274</orcidid></search><sort><creationdate>20210115</creationdate><title>Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection</title><author>Yu, Rentao ; Tan, Shun ; Dan, Yunjie ; Lu, Yanqiu ; Zhang, Juan ; Tan, Zhaoxia ; He, Xiaoqing ; Xiang, Xiaomei ; Zhou, Yi ; Guo, Yanzhi ; Deng, Guohong ; Chen, Yaokai ; Tan, Wenting</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-d9359cf775d3c2f686679b862665123c40ca63fa17f0dcfb8b483b8cfdcf7b1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Chronic hepatitis B</topic><topic>Coinfection - drug therapy</topic><topic>Coinfection - virology</topic><topic>COVID-19</topic><topic>COVID-19 - drug therapy</topic><topic>COVID-19 - virology</topic><topic>Female</topic><topic>HBV</topic><topic>Hepatitis B, Chronic - drug therapy</topic><topic>Hepatitis B, Chronic - virology</topic><topic>Humans</topic><topic>Liver injury</topic><topic>Male</topic><topic>Middle Aged</topic><topic>SARS-CoV-2</topic><topic>Virus Activation</topic><topic>Virus Shedding</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Rentao</creatorcontrib><creatorcontrib>Tan, Shun</creatorcontrib><creatorcontrib>Dan, Yunjie</creatorcontrib><creatorcontrib>Lu, Yanqiu</creatorcontrib><creatorcontrib>Zhang, Juan</creatorcontrib><creatorcontrib>Tan, Zhaoxia</creatorcontrib><creatorcontrib>He, Xiaoqing</creatorcontrib><creatorcontrib>Xiang, Xiaomei</creatorcontrib><creatorcontrib>Zhou, Yi</creatorcontrib><creatorcontrib>Guo, Yanzhi</creatorcontrib><creatorcontrib>Deng, Guohong</creatorcontrib><creatorcontrib>Chen, Yaokai</creatorcontrib><creatorcontrib>Tan, Wenting</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Virology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Rentao</au><au>Tan, Shun</au><au>Dan, Yunjie</au><au>Lu, Yanqiu</au><au>Zhang, Juan</au><au>Tan, Zhaoxia</au><au>He, Xiaoqing</au><au>Xiang, Xiaomei</au><au>Zhou, Yi</au><au>Guo, Yanzhi</au><au>Deng, Guohong</au><au>Chen, Yaokai</au><au>Tan, Wenting</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection</atitle><jtitle>Virology (New York, N.Y.)</jtitle><addtitle>Virology</addtitle><date>2021-01-15</date><risdate>2021</risdate><volume>553</volume><spage>131</spage><epage>134</epage><pages>131-134</pages><issn>0042-6822</issn><eissn>1096-0341</eissn><abstract>In patients coinfected with SARS-CoV-2 and HBV, liver injury was common. However, the interactions between SARS-CoV-2 and HBV coinfection remained unknown. Sixty-seven COVID-19 patients from the previous cohort were enrolled and classified into 2 groups (7 with HBsAg+ and 60 with HBsAg-). The association of HBV- and SARS-CoV-2-related markers were analyzed. During the acute course of SARS-CoV-2 infection, markers of HBV replication did not extensively fluctuate during SARS-CoV-2 infection. Coinfection with HBV did not extend the viral shedding cycle or incubation periods of SARS-CoV-2. Effects of SARS-CoV-2 on the dynamics of chronic HBV infection seemed not apparent. SARS-CoV-2 infection would not be the source of HBV reactivation in these individuals.
•The direct interactions between SARS-CoV-2 and HBV coinfection is important in clinics.•Effects of SARS-CoV-2 on the dynamics of chronic HBV infection seemed not apparent.•SARS-CoV-2 infection would not be the source of HBV reactivation.•Coinfection of HBV did not increase the severity of diseases or duration of hospitalization.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33276282</pmid><doi>10.1016/j.virol.2020.11.012</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-3229-0108</orcidid><orcidid>https://orcid.org/0000-0003-4952-9274</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Chronic hepatitis B Coinfection - drug therapy Coinfection - virology COVID-19 COVID-19 - drug therapy COVID-19 - virology Female HBV Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - virology Humans Liver injury Male Middle Aged SARS-CoV-2 Virus Activation Virus Shedding |
| title | Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection |
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