Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection

In patients coinfected with SARS-CoV-2 and HBV, liver injury was common. However, the interactions between SARS-CoV-2 and HBV coinfection remained unknown. Sixty-seven COVID-19 patients from the previous cohort were enrolled and classified into 2 groups (7 with HBsAg+ and 60 with HBsAg-). The association of HBV- and SARS-CoV-2-related markers were analyzed. During the acute course of SARS-CoV-2 infection, markers of HBV replication did not extensively fluctuate during SARS-CoV-2 infection. Coinfection with HBV did not extend the viral shedding cycle or incubation periods of SARS-CoV-2. Effects of SARS-CoV-2 on the dynamics of chronic HBV infection seemed not apparent. SARS-CoV-2 infection would not be the source of HBV reactivation in these individuals. •The direct interactions between SARS-CoV-2 and HBV coinfection is important in clinics.•Effects of SARS-CoV-2 on the dynamics of chronic HBV infection seemed not apparent.•SARS-CoV-2 infection would not be the source of HBV reactivation.•Coinfection of HBV did not increase the severity of diseases or duration of hospitalization.