Association of different oral anticoagulants use with renal function worsening in patients with atrial fibrillation: A multicentre cohort study

Association of different oral anticoagulants use with renal function worsening in patients with atrial fibrillation: A multicentre cohort study

Aims To investigate the decline of estimated glomerular filtration rate (eGFR) in patients with atrial fibrillation (AF) treated with vitamin K antagonists (VKAs) or non‐VKA oral anticoagulants (NOACs). Methods Multicentre prospective cohort study including 1667 patients with nonvalvular AF. The eGF...

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Veröffentlicht in:British journal of clinical pharmacology 2020-12, Vol.86 (12), p.2455-2463
Hauptverfasser: Pastori, Daniele, Ettorre, Evaristo, Lip, Gregory Y.H., Sciacqua, Angela, Perticone, Francesco, Melillo, Francesco, Godino, Cosmo, Marcucci, Rossella, Berteotti, Martina, Violi, Francesco, Pignatelli, Pasquale, Saliola, Mirella, Menichelli, Danilo, Casciaro, Marco Antonio, Menafra, Vito
Format: Artikel
Sprache:eng
Schlagworte:
anticoagulation treatment
atrial fibrillation
direct oral anticoagulants
Original
renal failure
warfarin
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Zusammenfassung:Aims To investigate the decline of estimated glomerular filtration rate (eGFR) in patients with atrial fibrillation (AF) treated with vitamin K antagonists (VKAs) or non‐VKA oral anticoagulants (NOACs). Methods Multicentre prospective cohort study including 1667 patients with nonvalvular AF. The eGFR was assessed by the CKD‐EPI formula at baseline and during follow‐up. The primary endpoint of the study was the median annual decline of eGFR according to VKA (n = 743) or NOAC (n = 924) use. As secondary endpoints, we analysed the transition to eGFR
ISSN:0306-5251
1365-2125
DOI:10.1111/bcp.14350