Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters
Coronavirus disease 2019 (COVID-19) in humans is often a clinically mild illness, but some individuals develop severe pneumonia, respiratory failure and death 1 – 4 . Studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in hamsters 5 – 7 and nonhuman primates 8 – 10 have...
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Veröffentlicht in: | Nature medicine 2020-11, Vol.26 (11), p.1694-1700 |
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Zusammenfassung: | Coronavirus disease 2019 (COVID-19) in humans is often a clinically mild illness, but some individuals develop severe pneumonia, respiratory failure and death
1
–
4
. Studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in hamsters
5
–
7
and nonhuman primates
8
–
10
have generally reported mild clinical disease, and preclinical SARS-CoV-2 vaccine studies have demonstrated reduction of viral replication in the upper and lower respiratory tracts in nonhuman primates
11
–
13
. Here we show that high-dose intranasal SARS-CoV-2 infection in hamsters results in severe clinical disease, including high levels of virus replication in tissues, extensive pneumonia, weight loss and mortality in a subset of animals. A single immunization with an adenovirus serotype 26 vector-based vaccine expressing a stabilized SARS-CoV-2 spike protein elicited binding and neutralizing antibody responses and protected against SARS-CoV-2-induced weight loss, pneumonia and mortality. These data demonstrate vaccine protection against SARS-CoV-2 clinical disease. This model should prove useful for preclinical studies of SARS-CoV-2 vaccines, therapeutics and pathogenesis.
A single immunization with an adenovirus vector-based vaccine expressing a stabilized SARS-CoV-2 spike protein induces protection against SARS-CoV-2-induced weight loss, pneumonia and mortality in hamsters. |
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ISSN: | 1078-8956 1546-170X 1546-170X |
DOI: | 10.1038/s41591-020-1070-6 |