Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery

Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery

An amphiphilic core/shell-type polymer-based drug carrier system (HPAE- PCL-b -MPEG), composed of hyperbranched poly(aminoester)-based polymer (HPAE) as the core building block and poly(ethylene glycol)-b - poly(ε-caprolactone) diblock polymers (MPEG-b -PCL) as the shell building block, was designed...

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Veröffentlicht in:Turkish journal of chemistry 2020-01, Vol.44 (2), p.518-534
Hauptverfasser: Bal ÖztÜrk, Ayça, OĞuz, Nesrin, Tekarslan Şahİn, Hande, Emİk, Serkan, AlarÇİn, Emine
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container_end_page 534
container_issue 2
container_start_page 518
container_title Turkish journal of chemistry
container_volume 44
creator Bal ÖztÜrk, Ayça
OĞuz, Nesrin
Tekarslan Şahİn, Hande
Emİk, Serkan
AlarÇİn, Emine
description An amphiphilic core/shell-type polymer-based drug carrier system (HPAE- PCL-b -MPEG), composed of hyperbranched poly(aminoester)-based polymer (HPAE) as the core building block and poly(ethylene glycol)-b - poly(ε-caprolactone) diblock polymers (MPEG-b -PCL) as the shell building block, was designed. The synthesized polymers were characterized with FTIR, 1 H NMR, 13 C NMR, and GPC analysis. Monodisperse HPAE-PCL-b - MPEG nanoparticles with dimensions of < 200 nm and polydispersity index of < 0.5 were prepared by nanoprecipitation method and characterized with SEM, particle size, and zeta potential analysis. 5-Fluorouracil was encapsulated within HPAE-PCL-b -MPEG nanoparticles. In vitro drug release profiles and cytotoxicity of blank and 5-fluorouracil-loaded nanoparticles were examined against the human colon cancer HCT116 cell line. All results suggest that HPAE-PCL-b - MPEG nanoparticles offer an alternative and effective drug nanocarrier system for drug delivery applications.
doi_str_mv 10.3906/kim-1910-35
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title Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery
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