Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2

The outbreak of COVID-19 by the end of 2019 has posed serious health threats to humanity and jeopardized the global economy. However, no effective drugs are available to treat COVID-19 currently and there is a great demand to fight against it. Here, we combined computational screening and an efficie...

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Veröffentlicht in:	ACS pharmacology & translational science 2020-12, Vol.3 (6), p.1361-1370
Hauptverfasser:	Liu, Ke, Zou, Rongfeng, Cui, Wenqiang, Li, Meiqing, Wang, Xueying, Dong, Junlin, Li, Hongchun, Li, Hongpei, Wang, Peihui, Shao, Ximing, Su, Wu, Chan, H. C. Stephen, Li, Hongchang, Yuan, Shuguang
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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Zusammenfassung:	The outbreak of COVID-19 by the end of 2019 has posed serious health threats to humanity and jeopardized the global economy. However, no effective drugs are available to treat COVID-19 currently and there is a great demand to fight against it. Here, we combined computational screening and an efficient cellular pseudotyped virus system, confirming that clinical HDAC inhibitors can efficiently prevent SARS-CoV-2 and potentially be used to fight against COVID-19.
ISSN:	2575-9108 2575-9108
DOI:	10.1021/acsptsci.0c00163