Medulloblastoma cells resemble neuronal progenitors in their differentiation

Medulloblastoma cells resemble neuronal progenitors in their differentiation

Medulloblastoma (MB) often originate from cerebellar granule neuron precursors (GNPs). We recently found that medulloblastoma cells undergo differentiation as GNPs. Differentiated MB cells have permanently lost their proliferative capacity and tumorigenicity. The differentiation of MB cells is drive...

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Veröffentlicht in:Molecular & cellular oncology 2020-11, Vol.7 (6), p.1810514-1810514
Hauptverfasser: Guo, Duancheng, Qu, Yanghui, Yang, Yijun, Yang, Zeng-Jie
Format: Artikel
Sprache:eng
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differentiation
EZH2
hedgehog pathway
Medulloblastoma
NeuroD1
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Zusammenfassung:Medulloblastoma (MB) often originate from cerebellar granule neuron precursors (GNPs). We recently found that medulloblastoma cells undergo differentiation as GNPs. Differentiated MB cells have permanently lost their proliferative capacity and tumorigenicity. The differentiation of MB cells is driven by the transcription factor NeuroD1 (Neurogenic differentiation 1), and NeuroD1 expression in MB cells is repressed by EZH2-mediated H3K27me3.
ISSN:2372-3556
2372-3556
DOI:10.1080/23723556.2020.1810514