Localized translation on the mitotic apparatus: A history and perspective

Localized translation is a proposed biological event that allows mRNA to be translated on site, providing an additional level of protein regulation within a cell. Examples of localized translation have been found or proposed in a variety of cellular contexts from neurons to cancer cells and implicated in both normal development and disease for over a half century. For example, mRNA translation on the mitotic apparatus (MA) was initially hypothesized in the 1950–60s. However, its proof of existence, biological significance and mechanistic details have remained sparse and it is still unclear how well conserved this mechanism may be among different cell types or organisms. In this review, we provide a brief historic summary of translation on the MA and discuss how current and future work may help us understand this biological process that provides a subcellular level of regulation in protein synthesis within a cell. •A historic summary for a biological process of localized translation on the mitotic apparatus.•A brief overview of the proposed physiological significance and mechanism of localized translation.•A summary of future questions to be addressed regarding localized translation on the mitotic apparatus.