B-lymphoblastic leukemia arising in a patient with chronic neutrophilic leukemia

•We report the first identified case of chronic neutrophilic leukemia with transformation to B-lymphoblastic leukemia.•Genetic alterations involving CSF3R, ASXL1, SRSF2, and RUNX1 contributed to the unusual progression and may drive B-cell leukemogenesis.

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Bibliographische Detailangaben
Veröffentlicht in:	Blood advances 2020-11, Vol.4 (21), p.5389-5392
Hauptverfasser:	Boddy, Craig S., Tan, Brent T., Aoki, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Exceptional Case Report Humans Leukemia, B-Cell Leukemia, Neutrophilic, Chronic - diagnosis Leukemia, Neutrophilic, Chronic - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma
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Beschreibung
Zusammenfassung:	•We report the first identified case of chronic neutrophilic leukemia with transformation to B-lymphoblastic leukemia.•Genetic alterations involving CSF3R, ASXL1, SRSF2, and RUNX1 contributed to the unusual progression and may drive B-cell leukemogenesis.
ISSN:	2473-9529 2473-9537
DOI:	10.1182/bloodadvances.2020003109