Podoplanin is expressed at the invasive front of esophageal squamous cell carcinomas and is involved in collective cell invasion

The expression of podoplanin is reportedly involved in collective cell invasion, which is independent from the epithelial–mesenchymal transition (EMT). We focused on the expression of podoplanin in esophageal squamous cell carcinomas (ESCC) and investigated the correlation of podoplanin and EMT‐rela...

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Veröffentlicht in:	Cancer science 2013-12, Vol.104 (12), p.1718-1725
Hauptverfasser:	Nakashima, Yuichiro, Yoshinaga, Keiji, Kitao, Hiroyuki, Ando, Koji, Kimura, Yasue, Saeki, Hiroshi, Oki, Eiji, Morita, Masaru, Kakeji, Yoshihiro, Hirahashi, Minako, Oda, Yoshinao, Maehara, Yoshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - metabolism Cadherins - biosynthesis Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Cell Line, Tumor Cell Movement - genetics Epithelial-Mesenchymal Transition Esophageal Neoplasms - metabolism Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Female Humans Lymphatic Metastasis Male Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Middle Aged Neoplasm Invasiveness Original RNA Interference RNA, Small Interfering Vimentin - biosynthesis Wound Healing - genetics
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Zusammenfassung:	The expression of podoplanin is reportedly involved in collective cell invasion, which is independent from the epithelial–mesenchymal transition (EMT). We focused on the expression of podoplanin in esophageal squamous cell carcinomas (ESCC) and investigated the correlation of podoplanin and EMT‐related markers, and evaluated its prognostic significance. Five ESCC cell lines were subjected to western blot analysis for podoplanin and EMT markers. The effects of podoplanin on EMT and carcinoma invasion were evaluated with wound healing assays, invasion assays and 3‐D culture. Transfection of ectopic podoplanin into a podoplanin‐negative ESCC cell line (TE‐15) induced cell migration and invasive activity (P
ISSN:	1347-9032 1349-7006
DOI:	10.1111/cas.12286