Efficacy of Tocilizumab in Patients Hospitalized with Covid-19

The efficacy of tocilizumab was tested in a randomized, controlled trial involving patients with Covid-19 who had fever, pulmonary infiltrates, or a need for supplemental oxygen. The treatment had no significant effect on disease progression, independence from supplemental oxygen, or death.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2020-12, Vol.383 (24), p.2333-2344
Hauptverfasser:	Stone, John H, Frigault, Matthew J, Serling-Boyd, Naomi J, Fernandes, Ana D, Harvey, Liam, Foulkes, Andrea S, Horick, Nora K, Healy, Brian C, Shah, Ruta, Bensaci, Ana Maria, Woolley, Ann E, Nikiforow, Sarah, Lin, Nina, Sagar, Manish, Schrager, Harry, Huckins, David S, Axelrod, Matthew, Pincus, Michael D, Fleisher, Jorge, Sacks, Chana A, Dougan, Michael, North, Crystal M, Halvorsen, Yuan-Di, Thurber, Tara K, Dagher, Zeina, Scherer, Allison, Wallwork, Rachel S, Kim, Arthur Y, Schoenfeld, Sara, Sen, Pritha, Neilan, Tomas G, Perugino, Cory A, Unizony, Sebastian H, Collier, Deborah S, Matza, Mark A, Yinh, Janeth M, Bowman, Kathryn A, Meyerowitz, Eric, Zafar, Amna, Drobni, Zsofia D, Bolster, Marcy B, Kohler, Minna, D’Silva, Kristin M, Dau, Jonathan, Lockwood, Megan M, Cubbison, Caroline, Weber, Brittany N, Mansour, Michael K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Aged, 80 and over Antibodies, Monoclonal, Humanized - therapeutic use Body temperature Body weight Boston Clinical trials Confidence intervals Coronaviridae Coronaviruses COVID-19 COVID-19 - drug therapy COVID-19 - mortality Cytokines Death Disease Progression Double-Blind Method Double-blind studies Female Fever Humans Immunosuppressive agents Interleukin 6 Intubation Intubation - statistics & numerical data Male Mechanical ventilation Middle Aged Monoclonal antibodies Original Oxygen Patients Population Receptors, Interleukin-6 - antagonists & inhibitors Respiratory Therapy Severe acute respiratory syndrome coronavirus 2 Statistical analysis Treatment Failure Ventilators Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The efficacy of tocilizumab was tested in a randomized, controlled trial involving patients with Covid-19 who had fever, pulmonary infiltrates, or a need for supplemental oxygen. The treatment had no significant effect on disease progression, independence from supplemental oxygen, or death.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2028836