Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a

Abstract The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large c...

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Veröffentlicht in:	Clinical infectious diseases 2020-11, Vol.71 (8), p.e215-e217
Hauptverfasser:	Popping, Stephanie, Verwijs, Rosanne, Cuypers, Lize, Claassen, Mark A, van den Berk, Guido E, De Weggheleire, Anja, Arends, Joop E, Boerekamps, Anne, Molenkamp, Richard, Koopmans, Marion P, Verbon, Annelies, Boucher, Charles A B, Rijnders, Bart J, van de Vijver, David A M C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Drug Resistance, Viral - genetics Genotype Hepacivirus - genetics Hepatitis C - drug therapy Hepatitis C - epidemiology Hepatitis C, Chronic - drug therapy Homosexuality, Male Humans Male Online Only Phylogeny Sexual and Gender Minorities Viral Nonstructural Proteins - genetics
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Zusammenfassung:	Abstract The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96% harbored NS5A M28V RAS.
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/ciaa145