Bioinspired bone therapies using naringin: applications and advances

•Natural compounds represent an emerging class of therapeutics for skeletal diseases.•Naringin exhibits pro-osteogenic and antiresorptive effects in preclinical studies.•A thorough overview of naringin bioactivity in different bone disorders is provided.•Controlled delivery of naringin in bone tissues holds an untapped potential. The use of natural compounds for treating chronic bone diseases holds remarkable potential. Among these therapeutics, naringin, a flavanone glycoside, represents one of the most promising candidates owing to its multifaceted effect on bone tissues. This review provides an up-to-date overview on naringin applications in the treatment of bone disorders, such as osteoporosis and osteoarthritis, and further highlights its potential for stem cell pro-osteogenic differentiation therapies. A critical perspective on naringin clinical translation is also provided. The topic is discussed in light of recently developed biomaterial-based approaches that potentiate its bioavailability and bioactivity. Overall, the reported pro-osteogenic, antiresorptive and antiadipogenic properties establish this flavanone as an exciting candidate for application in bone tissue engineering and regenerative medicine.