Decreased hepatitis B virus vaccine response among HIV-positive infants compared with HIV-negative infants in Botswana

We sought to determine vaccine antibody titres and the prevalence of hepatitis B surface antigen (HBsAg) in both HIV-positive and HIV-negative infants born to HIV-positive mothers in Botswana. This was a retrospective cross-sectional study using 449 archived dried blood spot samples from both HIV-po...

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Veröffentlicht in:	AIDS (London) 2022-05, Vol.36 (6), p.755-762
Hauptverfasser:	Shaver, Zachary M., Anderson, Motswedi, Bhebhe, Lynnette, Baruti, Kabo, Choga, Wonderful T., Ngidi, Julia, Mbangiwa, Tshepiso, Tau, Modiri, Setlhare, Ditiro R., Melamu, Pinkie, Phinius, Bonolo B., Musonda, Rosemary, Mine, Madisa, Moyo, Sikhulile, Gaseitsiwe, Simani
Format:	Artikel
Sprache:	eng
Schlagworte:	Botswana - epidemiology Cross-Sectional Studies Female Hepatitis B - prevention & control Hepatitis B Antibodies Hepatitis B Surface Antigens Hepatitis B virus HIV Infections - complications HIV Seropositivity Humans Infant Infectious Disease Transmission, Vertical - prevention & control Retrospective Studies Viral Vaccines
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Zusammenfassung:	We sought to determine vaccine antibody titres and the prevalence of hepatitis B surface antigen (HBsAg) in both HIV-positive and HIV-negative infants born to HIV-positive mothers in Botswana. This was a retrospective cross-sectional study using 449 archived dried blood spot samples from both HIV-positive and HIV-negative infants collected between 2016 and 2018. We screened dried blood spot samples for HBsAg and determined hepatitis B surface antibody titres. We determined hepatitis B virus (HBV) genotypes by amplifying 415 base-pairs of the surface region. HIV-positive infants mounted a significantly lower immune response to the HBV vaccine (P
ISSN:	0269-9370 1473-5571
DOI:	10.1097/QAD.0000000000003183