Control of adhesive ligand density for modulation of nucleus pulposus cell phenotype

Control of adhesive ligand density for modulation of nucleus pulposus cell phenotype

Cells of the nucleus pulposus have been observed to undergo a shift from their notochordal-like juvenile phenotype to a more fibroblast-like state with age and maturation. It has been demonstrated that culture of degenerative adult human nucleus pulposus cells upon soft (

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Veröffentlicht in:Biomaterials 2020-08, Vol.250, p.120057-120057, Article 120057
Hauptverfasser: Barcellona, Marcos N., Speer, Julie E., Fearing, Bailey V., Jing, Liufang, Pathak, Amit, Gupta, Munish C., Buchowski, Jacob M., Kelly, Michael, Setton, Lori A.
Format: Artikel
Sprache:eng
Schlagworte:
Adhesives
Adult
Humans
Intervertebral Disc
Intervertebral Disc Degeneration
Laminin
Laminin-mimetic peptides
Ligand presentation
Ligands
Nucleus Pulposus
Phenotype
Substrate stiffness
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Beschreibung
Zusammenfassung:Cells of the nucleus pulposus have been observed to undergo a shift from their notochordal-like juvenile phenotype to a more fibroblast-like state with age and maturation. It has been demonstrated that culture of degenerative adult human nucleus pulposus cells upon soft (
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2020.120057