Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2
The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-sp...
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| Veröffentlicht in: | International immunopharmacology 2021-01, Vol.90, p.107172-107172, Article 107172 |
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| container_title | International immunopharmacology |
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| creator | Wei, Shuangshi Duan, Shengbao Liu, Xiaomei Wang, Hongmei Ding, Shaohua Chen, Yezhou Xie, Jinsong Tian, Jingjing Yu, Nong Ge, pingju Zhang, xinglin chen, Xiaohong Li, Yong Meng, Qinglin |
| description | The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19. |
| doi_str_mv | 10.1016/j.intimp.2020.107172 |
| format | Article |
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This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2020.107172</identifier><identifier>PMID: 33191178</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>ACE2 ; Angiotensin-converting enzyme 2 ; Angiotensin-Converting Enzyme 2 - metabolism ; Animals ; Antibodies ; Antibodies, Neutralizing - metabolism ; Antibodies, Neutralizing - therapeutic use ; Binding ; Chicken Egg Yolk Antibodies ; Chickens - immunology ; Coronaviruses ; COVID-19 ; COVID-19 - therapy ; Egg Yolk - metabolism ; Eggs ; Humans ; IgY ; Immunoglobulins - metabolism ; Immunoglobulins - therapeutic use ; Mutants ; Mutation - genetics ; Neutralizing ; Neutralizing agent ; Pandemics ; Protein Binding ; Proteins ; SARS-CoV-2 ; SARS-CoV-2 - genetics ; SARS-CoV-2 - metabolism ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Short Communication ; Spike Glycoprotein, Coronavirus - genetics ; Spike Glycoprotein, Coronavirus - metabolism ; Spike protein ; Spike protein variants ; Viral diseases ; Viruses ; Yolk</subject><ispartof>International immunopharmacology, 2021-01, Vol.90, p.107172-107172, Article 107172</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Jan 2021</rights><rights>2020 Elsevier B.V. All rights reserved. 2020 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-a03ac05f652a3c95e4b4c0f8861b22a77b927043b9a47b351cc3cefd321eceaf3</citedby><cites>FETCH-LOGICAL-c491t-a03ac05f652a3c95e4b4c0f8861b22a77b927043b9a47b351cc3cefd321eceaf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1567576920336390$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33191178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, Shuangshi</creatorcontrib><creatorcontrib>Duan, Shengbao</creatorcontrib><creatorcontrib>Liu, Xiaomei</creatorcontrib><creatorcontrib>Wang, Hongmei</creatorcontrib><creatorcontrib>Ding, Shaohua</creatorcontrib><creatorcontrib>Chen, Yezhou</creatorcontrib><creatorcontrib>Xie, Jinsong</creatorcontrib><creatorcontrib>Tian, Jingjing</creatorcontrib><creatorcontrib>Yu, Nong</creatorcontrib><creatorcontrib>Ge, pingju</creatorcontrib><creatorcontrib>Zhang, xinglin</creatorcontrib><creatorcontrib>chen, Xiaohong</creatorcontrib><creatorcontrib>Li, Yong</creatorcontrib><creatorcontrib>Meng, Qinglin</creatorcontrib><title>Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19.</description><subject>ACE2</subject><subject>Angiotensin-converting enzyme 2</subject><subject>Angiotensin-Converting Enzyme 2 - metabolism</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Neutralizing - metabolism</subject><subject>Antibodies, Neutralizing - therapeutic use</subject><subject>Binding</subject><subject>Chicken Egg Yolk Antibodies</subject><subject>Chickens - immunology</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - therapy</subject><subject>Egg Yolk - metabolism</subject><subject>Eggs</subject><subject>Humans</subject><subject>IgY</subject><subject>Immunoglobulins - metabolism</subject><subject>Immunoglobulins - therapeutic use</subject><subject>Mutants</subject><subject>Mutation - genetics</subject><subject>Neutralizing</subject><subject>Neutralizing agent</subject><subject>Pandemics</subject><subject>Protein Binding</subject><subject>Proteins</subject><subject>SARS-CoV-2</subject><subject>SARS-CoV-2 - genetics</subject><subject>SARS-CoV-2 - metabolism</subject><subject>Severe acute respiratory syndrome</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Short Communication</subject><subject>Spike Glycoprotein, Coronavirus - genetics</subject><subject>Spike Glycoprotein, Coronavirus - metabolism</subject><subject>Spike protein</subject><subject>Spike protein variants</subject><subject>Viral diseases</subject><subject>Viruses</subject><subject>Yolk</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV2L1DAUhoMo7rr6D0QC3qwXHfPRNu2NMJRRFxYEV4W9Cml62slMm3STdMB_b8ZZ148LrxJOnvOevOdF6CUlK0po-Xa3MjaaaV4xwo4lQQV7hM5pJaqMClI8TveiFFkhyvoMPQthR0iq5_QpOuOc1pSK6hzNzdboPVi8GQZ868Y9XifV1nUGAr68Gm7DG9yOTu9x3AJuje2MHbDr8bSM0cwj4Jv155uscd8yhsNs9oBn7yIYiw_KG2VjwNHh7TIpi9fNhj1HT3o1Bnhxf16gr-83X5qP2fWnD1fN-jrTeU1jpghXmhR9WTDFdV1A3uaa9FVV0pYxJURbs2SGt7XKRcsLqjXX0HecUdCgen6B3p1056WdoNNgo1ejnL2ZlP8unTLy7xdrtnJwBylKUqVFJYHLewHv7hYIUU4maBhHZcEtQbK8pISw-if6-h905xZvk71E1bSknDOSqPxEae9C8NA_fIYSeYxU7uQpUnmMVJ4iTW2v_jTy0PQrw99OIa3zYMDLoA1YDZ3xoKPsnPn_hB_GErOP</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Wei, Shuangshi</creator><creator>Duan, Shengbao</creator><creator>Liu, Xiaomei</creator><creator>Wang, Hongmei</creator><creator>Ding, Shaohua</creator><creator>Chen, Yezhou</creator><creator>Xie, Jinsong</creator><creator>Tian, Jingjing</creator><creator>Yu, Nong</creator><creator>Ge, pingju</creator><creator>Zhang, xinglin</creator><creator>chen, Xiaohong</creator><creator>Li, Yong</creator><creator>Meng, Qinglin</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210101</creationdate><title>Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2</title><author>Wei, Shuangshi ; Duan, Shengbao ; Liu, Xiaomei ; Wang, Hongmei ; Ding, Shaohua ; Chen, Yezhou ; Xie, Jinsong ; Tian, Jingjing ; Yu, Nong ; Ge, pingju ; Zhang, xinglin ; chen, Xiaohong ; Li, Yong ; Meng, Qinglin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-a03ac05f652a3c95e4b4c0f8861b22a77b927043b9a47b351cc3cefd321eceaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>ACE2</topic><topic>Angiotensin-converting enzyme 2</topic><topic>Angiotensin-Converting Enzyme 2 - metabolism</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Neutralizing - metabolism</topic><topic>Antibodies, Neutralizing - therapeutic use</topic><topic>Binding</topic><topic>Chicken Egg Yolk Antibodies</topic><topic>Chickens - immunology</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - therapy</topic><topic>Egg Yolk - metabolism</topic><topic>Eggs</topic><topic>Humans</topic><topic>IgY</topic><topic>Immunoglobulins - metabolism</topic><topic>Immunoglobulins - therapeutic use</topic><topic>Mutants</topic><topic>Mutation - genetics</topic><topic>Neutralizing</topic><topic>Neutralizing agent</topic><topic>Pandemics</topic><topic>Protein Binding</topic><topic>Proteins</topic><topic>SARS-CoV-2</topic><topic>SARS-CoV-2 - genetics</topic><topic>SARS-CoV-2 - metabolism</topic><topic>Severe acute respiratory syndrome</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Short Communication</topic><topic>Spike Glycoprotein, Coronavirus - genetics</topic><topic>Spike Glycoprotein, Coronavirus - metabolism</topic><topic>Spike protein</topic><topic>Spike protein variants</topic><topic>Viral diseases</topic><topic>Viruses</topic><topic>Yolk</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Shuangshi</creatorcontrib><creatorcontrib>Duan, Shengbao</creatorcontrib><creatorcontrib>Liu, Xiaomei</creatorcontrib><creatorcontrib>Wang, Hongmei</creatorcontrib><creatorcontrib>Ding, Shaohua</creatorcontrib><creatorcontrib>Chen, Yezhou</creatorcontrib><creatorcontrib>Xie, Jinsong</creatorcontrib><creatorcontrib>Tian, Jingjing</creatorcontrib><creatorcontrib>Yu, Nong</creatorcontrib><creatorcontrib>Ge, pingju</creatorcontrib><creatorcontrib>Zhang, xinglin</creatorcontrib><creatorcontrib>chen, Xiaohong</creatorcontrib><creatorcontrib>Li, Yong</creatorcontrib><creatorcontrib>Meng, Qinglin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Shuangshi</au><au>Duan, Shengbao</au><au>Liu, Xiaomei</au><au>Wang, Hongmei</au><au>Ding, Shaohua</au><au>Chen, Yezhou</au><au>Xie, Jinsong</au><au>Tian, Jingjing</au><au>Yu, Nong</au><au>Ge, pingju</au><au>Zhang, xinglin</au><au>chen, Xiaohong</au><au>Li, Yong</au><au>Meng, Qinglin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>90</volume><spage>107172</spage><epage>107172</epage><pages>107172-107172</pages><artnum>107172</artnum><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33191178</pmid><doi>10.1016/j.intimp.2020.107172</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International immunopharmacology, 2021-01, Vol.90, p.107172-107172, Article 107172 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | ACE2 Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - metabolism Animals Antibodies Antibodies, Neutralizing - metabolism Antibodies, Neutralizing - therapeutic use Binding Chicken Egg Yolk Antibodies Chickens - immunology Coronaviruses COVID-19 COVID-19 - therapy Egg Yolk - metabolism Eggs Humans IgY Immunoglobulins - metabolism Immunoglobulins - therapeutic use Mutants Mutation - genetics Neutralizing Neutralizing agent Pandemics Protein Binding Proteins SARS-CoV-2 SARS-CoV-2 - genetics SARS-CoV-2 - metabolism Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Short Communication Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - metabolism Spike protein Spike protein variants Viral diseases Viruses Yolk |
| title | Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2 |
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