Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2

The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-sp...

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Veröffentlicht in:	International immunopharmacology 2021-01, Vol.90, p.107172-107172, Article 107172
Hauptverfasser:	Wei, Shuangshi, Duan, Shengbao, Liu, Xiaomei, Wang, Hongmei, Ding, Shaohua, Chen, Yezhou, Xie, Jinsong, Tian, Jingjing, Yu, Nong, Ge, pingju, Zhang, xinglin, chen, Xiaohong, Li, Yong, Meng, Qinglin
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - metabolism Animals Antibodies Antibodies, Neutralizing - metabolism Antibodies, Neutralizing - therapeutic use Binding Chicken Egg Yolk Antibodies Chickens - immunology Coronaviruses COVID-19 COVID-19 - therapy Egg Yolk - metabolism Eggs Humans IgY Immunoglobulins - metabolism Immunoglobulins - therapeutic use Mutants Mutation - genetics Neutralizing Neutralizing agent Pandemics Protein Binding Proteins SARS-CoV-2 SARS-CoV-2 - genetics SARS-CoV-2 - metabolism Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Short Communication Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - metabolism Spike protein Spike protein variants Viral diseases Viruses Yolk
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Beschreibung
Zusammenfassung:	The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19.
ISSN:	1567-5769 1878-1705
DOI:	10.1016/j.intimp.2020.107172