Sex-specific DNA methylation differences in people exposed to polybrominated biphenyl

Michigan residents were exposed to polybrominated biphenyls (PBBs) when it was accidentally added to the food supply. Highly exposed individuals report sex-specific health problems, but the underlying biological mechanism behind these different health risks is not known. DNA methylation in blood fro...

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Veröffentlicht in:	Epigenomics 2020-05, Vol.12 (9), p.757-770
Hauptverfasser:	Curtis, Sarah W, Gerkowicz, Sabrina A, Cobb, Dawayland O, Kilaru, Varun, Terrell, Metrecia L, Marder, M Elizabeth, Barr, Dana Boyd, Marsit, Carmen J, Marcus, Michele, Conneely, Karen N, Smith, Alicia K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Binding Sites CpG Islands DNA Methylation EDC endocrine-disrupting compound Environmental Exposure environmental health epigenetics epigenome-wide association study EWAS Female Humans Male Middle Aged polybrominated biphenyl Polybrominated Biphenyls - toxicity Sex Characteristics sex differences sex specific Transcription Factors - metabolism Young Adult
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Zusammenfassung:	Michigan residents were exposed to polybrominated biphenyls (PBBs) when it was accidentally added to the food supply. Highly exposed individuals report sex-specific health problems, but the underlying biological mechanism behind these different health risks is not known. DNA methylation in blood from 381 women and 277 men with PBB exposure was analyzed with the MethylationEPIC BeadChip. 675 CpGs were associated with PBBs levels in males, while only 17 CpGs were associated in females (false discovery rate
ISSN:	1750-1911 1750-192X
DOI:	10.2217/epi-2019-0179