Enantioselective S−H Insertion Reactions of α‐Carbonyl Sulfoxonium Ylides
The first example of enantioselective S−H insertion reactions of sulfoxonium ylides is reported. Under the influence of thiourea catalysis, excellent levels of enantiocontrol (up to 95 % ee) and yields (up to 97 %) are achieved for 31 examples in S−H insertion reactions of aryl thiols and α‐carbonyl...
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Veröffentlicht in: | Angewandte Chemie International Edition 2020-09, Vol.59 (36), p.15554-15559 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The first example of enantioselective S−H insertion reactions of sulfoxonium ylides is reported. Under the influence of thiourea catalysis, excellent levels of enantiocontrol (up to 95 % ee) and yields (up to 97 %) are achieved for 31 examples in S−H insertion reactions of aryl thiols and α‐carbonyl sulfoxonium ylides.
The first enantioselective S−H insertion reaction of α‐carbonyl sulfoxonium ylides was developed under thiourea catalysis. Up to 95 % ee and 97 % isolated yields were obtained in 31 examples. |
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ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.202005563 |