Association of low FVC spirometric pattern with WTC occupational exposures

A reduced forced vital capacity without obstruction (low FVC) is the predominant spirometric abnormality reported in workers and volunteers exposed to dust, gases, and fumes at the World Trade Center (WTC) disaster site in 2001–2002. While low FVC has been associated with obesity and metabolic syndrome, its association with WTC occupational exposures has not been demonstrated. We estimated the prevalence of this abnormality and examined its association with WTC exposure level. Longitudinal study of the relation between arrival at the WTC site within 48 h and FVC below the lower limit of normal (FVC