Synthetic Virology: Building Viruses to Better Understand Them

Generally comprised of less than a dozen components, RNA viruses can be viewed as well-designed genetic circuits optimized to replicate and spread within a given host. Understanding the molecular design that enables this activity not only allows one to disrupt these circuits to study their biology,...

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Veröffentlicht in:Cold Spring Harbor perspectives in medicine 2020-11, Vol.10 (11), p.a038703
1. Verfasser: tenOever, Benjamin R
Format: Artikel
Sprache:eng
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Zusammenfassung:Generally comprised of less than a dozen components, RNA viruses can be viewed as well-designed genetic circuits optimized to replicate and spread within a given host. Understanding the molecular design that enables this activity not only allows one to disrupt these circuits to study their biology, but it provides a reprogramming framework to achieve novel outputs. Recent advances have enabled a "learning by building" approach to better understand virus biology and create valuable tools. Below is a summary of how modifying the preexisting genetic framework of influenza A virus has been used to track viral movement, understand virus replication, and identify host factors that engage this viral circuitry.
ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a038703