The Genetics of Aging: A Vertebrate Perspective

Aging negatively impacts vitality and health. Many genetic pathways that regulate aging were discovered in invertebrates. However, the genetics of aging is more complex in vertebrates because of their specialized systems. This Review discusses advances in the genetic regulation of aging in vertebrates from work in mice, humans, and organisms with exceptional lifespans. We highlight challenges for the future, including sex-dependent differences in lifespan and the interplay between genes and environment. We also discuss how the identification of reliable biomarkers of age and development of new vertebrate models can be leveraged for personalized interventions to counter aging and age-related diseases. As time marches on, aging causes a progressive decline in organismal integrity and homeostasis, prompting a rigorous search for the underlying genetic mechanisms. In this Review, Anne Brunet and colleagues outline recent progress in our understanding of the genetics of aging from a vertebrate perspective.