CXCL4 suppresses tolerogenic immune signature of monocyte‐derived dendritic cells

RNA sequencing and DNA methylomic profiling were performed after differentiating monocytes for 6 days into moDCs with/without CXCL4 presence. We show that CXCL4 downregulates genes associated with tolerogenicity in DCs including C1Q. Expression profiles of C1Q genes were negatively correlated with t...

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Veröffentlicht in:	European journal of immunology 2020-10, Vol.50 (10), p.1598-1601
Hauptverfasser:	Silva‐Cardoso, Sandra C., Tao, Weiyang, Fernández, Beatriz Malvar, Boes, Marianne, Radstake, Timothy R.D.J., Pandit, Aridaman
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmunity C1q Cell Differentiation Cells, Cultured Complement C1q - genetics CXCL4 Dendritic cells Dendritic Cells - immunology Deoxyribonucleic acid DNA DNA fingerprinting DNA methylation DNA sequencing Epigenome Humans Immune Tolerance Immunogenicity Letter to the Editor Letters to the Editor Monocytes Monocytes - immunology Monocyte‐derived dendritic cells Platelet Factor 4 - metabolism Ribonucleic acid RNA RNA sequencing Sequence Analysis, RNA Transcriptome
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