CXCL4 suppresses tolerogenic immune signature of monocyte‐derived dendritic cells

RNA sequencing and DNA methylomic profiling were performed after differentiating monocytes for 6 days into moDCs with/without CXCL4 presence. We show that CXCL4 downregulates genes associated with tolerogenicity in DCs including C1Q. Expression profiles of C1Q genes were negatively correlated with t...

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Veröffentlicht in:	European journal of immunology 2020-10, Vol.50 (10), p.1598-1601
Hauptverfasser:	Silva‐Cardoso, Sandra C., Tao, Weiyang, Fernández, Beatriz Malvar, Boes, Marianne, Radstake, Timothy R.D.J., Pandit, Aridaman
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmunity C1q Cell Differentiation Cells, Cultured Complement C1q - genetics CXCL4 Dendritic cells Dendritic Cells - immunology Deoxyribonucleic acid DNA DNA fingerprinting DNA methylation DNA sequencing Epigenome Humans Immune Tolerance Immunogenicity Letter to the Editor Letters to the Editor Monocytes Monocytes - immunology Monocyte‐derived dendritic cells Platelet Factor 4 - metabolism Ribonucleic acid RNA RNA sequencing Sequence Analysis, RNA Transcriptome
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Zusammenfassung:	RNA sequencing and DNA methylomic profiling were performed after differentiating monocytes for 6 days into moDCs with/without CXCL4 presence. We show that CXCL4 downregulates genes associated with tolerogenicity in DCs including C1Q. Expression profiles of C1Q genes were negatively correlated with their DNA methylation profiles and with immunogenic genes.
ISSN:	0014-2980 1521-4141
DOI:	10.1002/eji.201948341