Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome
Inflammasome is a complex composed of several proteins and an important part of the natural immune system. Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is composed of NLRP3, apoptosis associated speck like protein (ASC) and pro-caspase-1. It plays an importa...
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| Veröffentlicht in: | International journal of biological sciences 2020-01, Vol.16 (14), p.2752-2760 |
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| container_title | International journal of biological sciences |
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| creator | Wang, Honggang Shi, Xingzhuo Qiu, Mengyuan Lv, Shuangyu Zheng, Hong Niu, Baohua Liu, Huiyang |
| description | Inflammasome is a complex composed of several proteins and an important part of the natural immune system. Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is composed of NLRP3, apoptosis associated speck like protein (ASC) and pro-caspase-1. It plays an important role in many diseases. Hydrogen sulfide (H
S) is an important signaling molecule that regulates many physiological and pathological processes. Recent studies indicated that H
S played anti-inflammatory and pro-inflammatory roles in many diseases through influencing NLRP3 inflammasome, but its mechanism was not fully understood. This article reviewed the progress about the effects of H
S on NLRP3 inflammasome and its mechanisms involved in recent years to provide theoretical basis for in-depth study. |
| doi_str_mv | 10.7150/ijbs.47595 |
| format | Article |
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S) is an important signaling molecule that regulates many physiological and pathological processes. Recent studies indicated that H
S played anti-inflammatory and pro-inflammatory roles in many diseases through influencing NLRP3 inflammasome, but its mechanism was not fully understood. This article reviewed the progress about the effects of H
S on NLRP3 inflammasome and its mechanisms involved in recent years to provide theoretical basis for in-depth study.</description><identifier>ISSN: 1449-2288</identifier><identifier>EISSN: 1449-2288</identifier><identifier>DOI: 10.7150/ijbs.47595</identifier><identifier>PMID: 33110394</identifier><language>eng</language><publisher>Australia: Ivyspring International Publisher Pty Ltd</publisher><subject>Alzheimer's disease ; Apoptosis ; Atherosclerosis ; Autophagy ; Caspase-1 ; Cytokines ; Diabetes ; Endoplasmic reticulum ; Enzymes ; Hydrogen sulfide ; Immune system ; Inflammasomes ; Inflammation ; Kinases ; Liver ; Mammals ; Nucleotides ; Oligomerization ; Pathogenesis ; Physiology ; Poisoning ; Protein expression ; Proteins ; Review ; Rheumatism</subject><ispartof>International journal of biological sciences, 2020-01, Vol.16 (14), p.2752-2760</ispartof><rights>The author(s).</rights><rights>2020. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-a9df7ae377df0ba3be193d364efdff5b30585b9e8fd3396de059d225962abffb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586428/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586428/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33110394$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Honggang</creatorcontrib><creatorcontrib>Shi, Xingzhuo</creatorcontrib><creatorcontrib>Qiu, Mengyuan</creatorcontrib><creatorcontrib>Lv, Shuangyu</creatorcontrib><creatorcontrib>Zheng, Hong</creatorcontrib><creatorcontrib>Niu, Baohua</creatorcontrib><creatorcontrib>Liu, Huiyang</creatorcontrib><title>Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome</title><title>International journal of biological sciences</title><addtitle>Int J Biol Sci</addtitle><description>Inflammasome is a complex composed of several proteins and an important part of the natural immune system. Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is composed of NLRP3, apoptosis associated speck like protein (ASC) and pro-caspase-1. It plays an important role in many diseases. Hydrogen sulfide (H
S) is an important signaling molecule that regulates many physiological and pathological processes. Recent studies indicated that H
S played anti-inflammatory and pro-inflammatory roles in many diseases through influencing NLRP3 inflammasome, but its mechanism was not fully understood. This article reviewed the progress about the effects of H
S on NLRP3 inflammasome and its mechanisms involved in recent years to provide theoretical basis for in-depth study.</description><subject>Alzheimer's disease</subject><subject>Apoptosis</subject><subject>Atherosclerosis</subject><subject>Autophagy</subject><subject>Caspase-1</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Endoplasmic reticulum</subject><subject>Enzymes</subject><subject>Hydrogen sulfide</subject><subject>Immune system</subject><subject>Inflammasomes</subject><subject>Inflammation</subject><subject>Kinases</subject><subject>Liver</subject><subject>Mammals</subject><subject>Nucleotides</subject><subject>Oligomerization</subject><subject>Pathogenesis</subject><subject>Physiology</subject><subject>Poisoning</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Review</subject><subject>Rheumatism</subject><issn>1449-2288</issn><issn>1449-2288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkctKxDAUhoMo3jc-gATciDCaNEnbbAQZvIwMKl7WIWlOxg5tMiatMG9vvaKuTjj5-PkPH0J7lBwXVJCTem7SMS-EFCtok3IuR1lWlqu_3htoK6U5ISwXJVlHG4xRSpjkm-j6amljmIHHD33jagv4rtHLhLXHk3YRYqd9h-9DA9gs8cS7pgdf1X6Gb6b3dwzXw0a3rU6hhR205nSTYPdrbqOni_PH8dVoens5GZ9NRxUneTfS0rpCAysK64jRzACVzLKcg7POCcOIKIWRUDrLmMwtECFtlgmZZ9o4Z9g2Ov3MXfSmBVuB76Ju1CLWrY5LFXSt_v74-lnNwqsqRJnzrBwCDr8CYnjpIXWqrVMFTaM9hD6pjAtBC0FJMaAH_9B56KMfzlNDo5KTjFI-UEefVBVDShHcTxlK1Lsi9a5IfSga4P3f9X_QbyfsDRbgjZ0</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Wang, Honggang</creator><creator>Shi, Xingzhuo</creator><creator>Qiu, Mengyuan</creator><creator>Lv, Shuangyu</creator><creator>Zheng, Hong</creator><creator>Niu, Baohua</creator><creator>Liu, Huiyang</creator><general>Ivyspring International Publisher Pty Ltd</general><general>Ivyspring International Publisher</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200101</creationdate><title>Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome</title><author>Wang, Honggang ; 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Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is composed of NLRP3, apoptosis associated speck like protein (ASC) and pro-caspase-1. It plays an important role in many diseases. Hydrogen sulfide (H
S) is an important signaling molecule that regulates many physiological and pathological processes. Recent studies indicated that H
S played anti-inflammatory and pro-inflammatory roles in many diseases through influencing NLRP3 inflammasome, but its mechanism was not fully understood. This article reviewed the progress about the effects of H
S on NLRP3 inflammasome and its mechanisms involved in recent years to provide theoretical basis for in-depth study.</abstract><cop>Australia</cop><pub>Ivyspring International Publisher Pty Ltd</pub><pmid>33110394</pmid><doi>10.7150/ijbs.47595</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Alzheimer's disease Apoptosis Atherosclerosis Autophagy Caspase-1 Cytokines Diabetes Endoplasmic reticulum Enzymes Hydrogen sulfide Immune system Inflammasomes Inflammation Kinases Liver Mammals Nucleotides Oligomerization Pathogenesis Physiology Poisoning Protein expression Proteins Review Rheumatism |
| title | Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome |
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