Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome

Inflammasome is a complex composed of several proteins and an important part of the natural immune system. Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is composed of NLRP3, apoptosis associated speck like protein (ASC) and pro-caspase-1. It plays an important role in many diseases. Hydrogen sulfide (H S) is an important signaling molecule that regulates many physiological and pathological processes. Recent studies indicated that H S played anti-inflammatory and pro-inflammatory roles in many diseases through influencing NLRP3 inflammasome, but its mechanism was not fully understood. This article reviewed the progress about the effects of H S on NLRP3 inflammasome and its mechanisms involved in recent years to provide theoretical basis for in-depth study.