Cortical bone properties in the Brtl/+ mouse model of Osteogenesis imperfecta as evidenced by acoustic transmission microscopy

Higher skeletal fragility has been established for the Brtl/+ mouse model of osteogenesis imperfecta at the whole bone level, but previous investigations of mechanical properties at the bone material level were inconclusive. Bone material was analyzed separately at endosteal (ER) and periosteal regi...

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Veröffentlicht in:	Journal of the mechanical behavior of biomedical materials 2019-02, Vol.90, p.125-132
Hauptverfasser:	Blouin, S, Fratzl-Zelman, N, Roschger, A, Cabral, W A, Klaushofer, K, Marini, J C, Fratzl, P, Roschger, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomechanical Phenomena Cortical Bone - diagnostic imaging Cortical Bone - pathology Cortical Bone - physiopathology Disease Models, Animal Femur - diagnostic imaging Femur - pathology Femur - physiopathology Mechanical Phenomena Mice Microscopy, Acoustic Osteogenesis Imperfecta - diagnostic imaging Osteogenesis Imperfecta - pathology Osteogenesis Imperfecta - physiopathology
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Zusammenfassung:	Higher skeletal fragility has been established for the Brtl/+ mouse model of osteogenesis imperfecta at the whole bone level, but previous investigations of mechanical properties at the bone material level were inconclusive. Bone material was analyzed separately at endosteal (ER) and periosteal regions (PR) on transverse femoral midshaft sections for 2-month old mice (wild-type n = 6; Brtl/+ n = 6). Quantitative backscattered electron imaging revealed that the mass density computed from mineral density maps was higher in PR than in ER for both wild-type (+2.1%, p
ISSN:	1751-6161 1878-0180
DOI:	10.1016/j.jmbbm.2018.10.010