Tracking the carbons supplying gluconeogenesis

As the burden of type 2 diabetes mellitus (T2DM) grows in the 21st century, the need to understand glucose metabolism heightens. Increased gluconeogenesis is a major contributor to the hyperglycemia seen in T2DM. Isotope tracer experiments in humans and animals over several decades have offered insi...

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Veröffentlicht in:	The Journal of biological chemistry 2020-10, Vol.295 (42), p.14419-14429
Hauptverfasser:	Shah, Ankit M., Wondisford, Fredric E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbon - metabolism carbon flux Carbon Isotopes - metabolism Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Gluconeogenesis Glucose - metabolism Glycogen - metabolism Humans Hyperglycemia - metabolism Hyperglycemia - pathology isotopic tracer JBC Reviews mass spectrometry (MS) Metabolomics nuclear magnetic resonance (NMR) type 2 diabetes
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