Ultrasensitive CRISPR-based diagnostic for field-applicable detection of Plasmodium species in symptomatic and asymptomatic malaria

Asymptomatic carriers of Plasmodium parasites hamper malaria control and eradication. Achieving malaria eradication requires ultrasensitive diagnostics for low parasite density infections (

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Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-10, Vol.117 (41), p.25722-25731
Hauptverfasser:	Lee, Rose A., De Puig, Helena, Nguyen, Peter Q., Angenent-Mari, Nicolaas M., Donghia, Nina M., McGee, James P., Dvorin, Jeffrey D., Klapperich, Catherine M., Pollock, Nira R., Collins, James J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Assaying Asymptomatic Biological Sciences Blood Carrier State - diagnosis Carrier State - parasitology Clustered Regularly Interspaced Short Palindromic Repeats CRISPR Density Diagnostic systems Diagnostic Techniques and Procedures Erythrocytes Fluorescence Genetic Techniques Humans Infections Malaria Malaria - diagnosis Malaria - parasitology Nucleic acids Parasites Plasmodium Plasmodium - classification Plasmodium - genetics Plasmodium - isolation & purification Plasmodium - physiology Plasmodium falciparum Sample preparation Sensitivity Species Vector-borne diseases
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Beschreibung
Zusammenfassung:	Asymptomatic carriers of Plasmodium parasites hamper malaria control and eradication. Achieving malaria eradication requires ultrasensitive diagnostics for low parasite density infections (
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.2010196117