Retrospective analysis of safety and efficacy of anti-PD-1 therapy and radiation therapy in advanced melanoma: A bi-institutional study

Highlights•Worse baseline prognostic features for melanoma patients receiving RT vs no RT. •Similar OS with no RT, RT during anti-PD-1, or RT after anti-PD-1 therapy. •OS significantly worse with RT before anti-PD-1 therapy compared to no RT. •RT in close temporal proximity to anti-PD-1 therapy is w...

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Veröffentlicht in:	Radiotherapy and oncology 2019-09, Vol.138, p.114-120
Hauptverfasser:	Mowery, Yvonne M, Patel, Kirtesh, Chowdhary, Mudit, Rushing, Christel N, Roy Choudhury, Kingshuk, Lowe, Jared R, Olson, Adam C, Wisdom, Amy J, Salama, Joseph K, Hanks, Brent A, Khan, Mohammad K, Salama, April K.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies, Monoclonal, Humanized - administration & dosage Antineoplastic Agents, Immunological - administration & dosage Chemoradiotherapy Cohort Studies Dose fractionation Female Hematology, Oncology, and Palliative Medicine Humans Immunotherapy Male Melanoma Melanoma - drug therapy Melanoma - immunology Melanoma - radiotherapy Middle Aged Prognosis Programmed cell death 1 receptor Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - immunology Radiotherapy Retrospective Studies
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Zusammenfassung:	Highlights•Worse baseline prognostic features for melanoma patients receiving RT vs no RT. •Similar OS with no RT, RT during anti-PD-1, or RT after anti-PD-1 therapy. •OS significantly worse with RT before anti-PD-1 therapy compared to no RT. •RT in close temporal proximity to anti-PD-1 therapy is well tolerated.
ISSN:	0167-8140 1879-0887
DOI:	10.1016/j.radonc.2019.06.013