A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for millions of infections and hundreds of thousands of deaths globally. There are no widely available licensed therapeutics against SARS-CoV-2, highlighting an urgent need for effective interventions. The virus enters host...

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Veröffentlicht in:	The Journal of immunology (1950) 2020-08, Vol.205 (4), p.915-922
Hauptverfasser:	Alsoussi, Wafaa B, Turner, Jackson S, Case, James B, Zhao, Haiyan, Schmitz, Aaron J, Zhou, Julian Q, Chen, Rita E, Lei, Tingting, Rizk, Amena A, McIntire, Katherine M, Winkler, Emma S, Fox, Julie M, Kafai, Natasha M, Thackray, Larissa B, Hassan, Ahmed O, Amanat, Fatima, Krammer, Florian, Watson, Corey T, Kleinstein, Steven H, Fremont, Daved H, Diamond, Michael S, Ellebedy, Ali H
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme 2 Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antibodies, Neutralizing - immunology Antibodies, Neutralizing - pharmacology Antibodies, Neutralizing - therapeutic use Antibodies, Viral - immunology Antibodies, Viral - pharmacology Antibodies, Viral - therapeutic use Betacoronavirus - drug effects Chlorocebus aethiops Coronavirus Infections - drug therapy Coronavirus Infections - immunology Coronavirus Infections - virology COVID-19 Disease Models, Animal Epitope Mapping Female HEK293 Cells Humans Immunodominant Epitopes - immunology Mice Mice, Inbred C57BL Pandemics Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Pneumonia, Viral - drug therapy Pneumonia, Viral - immunology Pneumonia, Viral - virology Protein Interaction Domains and Motifs - genetics Protein Interaction Domains and Motifs - immunology SARS-CoV-2 Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - metabolism Transfection Vero Cells
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Zusammenfassung:	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for millions of infections and hundreds of thousands of deaths globally. There are no widely available licensed therapeutics against SARS-CoV-2, highlighting an urgent need for effective interventions. The virus enters host cells through binding of a receptor-binding domain within its trimeric spike glycoprotein to human angiotensin-converting enzyme 2. In this article, we describe the generation and characterization of a panel of murine mAbs directed against the receptor-binding domain. One mAb, 2B04, neutralized wild-type SARS-CoV-2 in vitro with remarkable potency (half-maximal inhibitory concentration of
ISSN:	0022-1767 1550-6606 1550-6606
DOI:	10.4049/jimmunol.2000583