HIV/SIV DNA vaccine combined with protein in a co-immunization protocol elicits highest humoral responses to envelope in mice and macaques

Highlights • DNA&protein co-immunization induces high antibody responses in mice and macaques. • EM-005 protein adjuvant further augments humoral immunity. • EM-005 enhances the maturation and cytokine production of DCs. • DNA&protein co-immunization provides a promising vaccine regimen for...

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Veröffentlicht in:	Vaccine 2013-08, Vol.31 (36), p.3747-3755
Hauptverfasser:	Li, Jinyao, Valentin, Antonio, Kulkarni, Viraj, Rosati, Margherita, Beach, Rachel Kelly, Alicea, Candido, Hannaman, Drew, Reed, Steven G, Felber, Barbara K, Pavlakis, George N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants Adjuvants, Immunologic - pharmacology AIDS Vaccines - administration & dosage AIDS Vaccines - immunology Allergy and Immunology Animals Antibody Applied microbiology Biological and medical sciences cell-mediated immunity Cellular responses Cross Protection Dendritic cell maturation dendritic cells Dendritic Cells - immunology Deoxyribonucleic acid DNA Electroporation Fundamental and applied biological sciences. Psychology HIV Antibodies - blood HIV Envelope Protein gp120 - immunology HIV Infections - immunology HIV Infections - prevention & control HIV-1 Human immunodeficiency virus humoral immunity Humoral responses immune response Immune system Immunity, Cellular Immunity, Humoral Immunization Immunogenicity interleukin-6 Interleukin-6 - immunology Macaca Membrane Glycoproteins - immunology Mice Mice, Inbred BALB C Microbiology Miscellaneous Neutralizing antibody Plasmids Proteins recombinant vaccines Simian Immunodeficiency Virus T-lymphocytes Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - administration & dosage Vaccines, DNA - immunology Viral Envelope Proteins - immunology Virology
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Beschreibung
Zusammenfassung:	Highlights • DNA&protein co-immunization induces high antibody responses in mice and macaques. • EM-005 protein adjuvant further augments humoral immunity. • EM-005 enhances the maturation and cytokine production of DCs. • DNA&protein co-immunization provides a promising vaccine regimen for HIV. • DNA&protein co-immunization for general vaccine application.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.04.037