Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

The Moderna mRNA-1273 vaccine, which elicited antibodies and T cells specific for the Covid-19 virus in adults 55 years of age or younger, elicited similarly high levels of neutralizing-antibody and CD4 T-cell responses in a small group of older adults, including those 71 years of age or older.

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Veröffentlicht in:	The New England journal of medicine 2020-12, Vol.383 (25), p.2427-2438
Hauptverfasser:	Anderson, Evan J, Rouphael, Nadine G, Widge, Alicia T, Jackson, Lisa A, Roberts, Paul C, Makhene, Mamodikoe, Chappell, James D, Denison, Mark R, Stevens, Laura J, Pruijssers, Andrea J, McDermott, Adrian B, Flach, Britta, Lin, Bob C, Doria-Rose, Nicole A, O’Dell, Sijy, Schmidt, Stephen D, Corbett, Kizzmekia S, Swanson, Phillip A, Padilla, Marcelino, Neuzil, Kathy M, Bennett, Hamilton, Leav, Brett, Makowski, Mat, Albert, Jim, Cross, Kaitlyn, Edara, Venkata Viswanadh, Floyd, Katharine, Suthar, Mehul S, Martinez, David R, Baric, Ralph, Buchanan, Wendy, Luke, Catherine J, Phadke, Varun K, Rostad, Christina A, Ledgerwood, Julie E, Graham, Barney S, Beigel, John H
Format:	Artikel
Sprache:	eng
Schlagworte:	2019-nCoV Vaccine mRNA-1273 Age Aged Allergies Antibodies Antibodies, Neutralizing - blood Antibodies, Viral - blood CD4 antigen Coronaviridae Coronaviruses COVID-19 COVID-19 - immunology COVID-19 - prevention & control COVID-19 Vaccines - administration & dosage COVID-19 Vaccines - adverse effects COVID-19 Vaccines - immunology Dose-Response Relationship, Drug Drug dosages Female Health care Humans Immunization Immunogenicity Infections Infectious diseases Lymphocytes T Male Medical research Middle Aged mRNA Myalgia Neutralization Tests Older people Original SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus Spike protein Statistical analysis T-Lymphocytes - physiology Vaccines
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Beschreibung
Zusammenfassung:	The Moderna mRNA-1273 vaccine, which elicited antibodies and T cells specific for the Covid-19 virus in adults 55 years of age or younger, elicited similarly high levels of neutralizing-antibody and CD4 T-cell responses in a small group of older adults, including those 71 years of age or older.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa2028436