Whole-genome sequencing reveals potent therapeutic strategy for monomorphic epitheliotropic intestinal T-cell lymphoma

Whole-genome sequencing reveals potent therapeutic strategy for monomorphic epitheliotropic intestinal T-cell lymphoma

•Whole genomic and transcriptomic analyses of MEITL revealed multiple potential therapeutic targets.•Synergistic effects of pimozide and romidepsin are shown in a well-characterized MEITL PDX model.

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Bibliographische Detailangaben
Veröffentlicht in:Blood advances 2020-10, Vol.4 (19), p.4769-4774
Hauptverfasser: Huang, Dachuan, Lim, Jing Quan, Cheah, Daryl Ming Zhe, Kahliab, Khalilatul Hanisah Binte Mohd, Laurensia, Yurike, Pang, Jane Wan Lu, Wong, Esther Kam Yin, Chia, Burton Kuan Hui, Goh, Jasmine, Zhang, Xiyun, Chan, Jason Yongsheng, Chow, Edward Kai-Hua, Tan, Soo Yong, Lim, Soon Thye, Ong, Choon Kiat
Format: Artikel
Sprache:eng
Schlagworte:
Humans
Lymphoma, T-Cell
Stimulus Report
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Beschreibung
Zusammenfassung:•Whole genomic and transcriptomic analyses of MEITL revealed multiple potential therapeutic targets.•Synergistic effects of pimozide and romidepsin are shown in a well-characterized MEITL PDX model.
ISSN:2473-9529
2473-9537
DOI:10.1182/bloodadvances.2020001782