Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology
The identification of cancer stem cells (CSCs) as initiators of carcinogenesis has revolutionized the era of cancer research and our perception for the disease treatment options. Additional CSC features, including self-renewal and migratory and invasive capabilities, have further justified these cel...
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container_title | International journal of molecular sciences |
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creator | Kyriazi, Athina A Papiris, Efstathios Kitsos Kalyvianakis, Konstantinos Sakellaris, George Baritaki, Stavroula |
description | The identification of cancer stem cells (CSCs) as initiators of carcinogenesis has revolutionized the era of cancer research and our perception for the disease treatment options. Additional CSC features, including self-renewal and migratory and invasive capabilities, have further justified these cells as putative diagnostic, prognostic, and therapeutic targets. Given the CSC plasticity, the identification of CSC-related biomarkers has been a serious burden in CSC characterization and therapeutic targeting. Over the past decades, a compelling amount of evidence has demonstrated critical regulatory functions of non-coding RNAs (ncRNAs) on the exclusive features of CSCs. We now know that ncRNAs may interfere with signaling pathways, vital for CSC phenotype maintenance, such as Notch, Wnt, and Hedgehog. Here, we discuss the multifaceted contribution of microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), as representative ncRNA classes, in sustaining the CSC-like traits, as well as the underlying molecular mechanisms of their action in various CSC types. We further discuss the use of CSC-related ncRNAs as putative biomarkers of high diagnostic, prognostic, and therapeutic value. |
doi_str_mv | 10.3390/ijms21186658 |
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Additional CSC features, including self-renewal and migratory and invasive capabilities, have further justified these cells as putative diagnostic, prognostic, and therapeutic targets. Given the CSC plasticity, the identification of CSC-related biomarkers has been a serious burden in CSC characterization and therapeutic targeting. Over the past decades, a compelling amount of evidence has demonstrated critical regulatory functions of non-coding RNAs (ncRNAs) on the exclusive features of CSCs. We now know that ncRNAs may interfere with signaling pathways, vital for CSC phenotype maintenance, such as Notch, Wnt, and Hedgehog. Here, we discuss the multifaceted contribution of microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), as representative ncRNA classes, in sustaining the CSC-like traits, as well as the underlying molecular mechanisms of their action in various CSC types. We further discuss the use of CSC-related ncRNAs as putative biomarkers of high diagnostic, prognostic, and therapeutic value.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21186658</identifier><identifier>PMID: 32932969</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Binding sites ; Biology ; Biomarkers ; Biomarkers, Tumor - genetics ; Cancer ; Carcinogenesis ; Carcinogens ; Cell growth ; Cell self-renewal ; Coding ; Diagnostic systems ; Epigenetics ; Gene expression ; Humans ; Invasiveness ; Metastasis ; MicroRNAs ; MicroRNAs - genetics ; miRNA ; Molecular modelling ; Neoplasms - genetics ; Neoplasms - pathology ; Neoplastic Stem Cells - metabolism ; Neoplastic Stem Cells - pathology ; Non-coding RNA ; Pathophysiology ; Phenotypes ; Prognosis ; Proteins ; Review ; RNA, Untranslated - genetics ; Signal transduction ; Signal Transduction - genetics ; Stem cells ; Therapeutic targets ; Wnt protein</subject><ispartof>International journal of molecular sciences, 2020-09, Vol.21 (18), p.6658</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). 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Additional CSC features, including self-renewal and migratory and invasive capabilities, have further justified these cells as putative diagnostic, prognostic, and therapeutic targets. Given the CSC plasticity, the identification of CSC-related biomarkers has been a serious burden in CSC characterization and therapeutic targeting. Over the past decades, a compelling amount of evidence has demonstrated critical regulatory functions of non-coding RNAs (ncRNAs) on the exclusive features of CSCs. We now know that ncRNAs may interfere with signaling pathways, vital for CSC phenotype maintenance, such as Notch, Wnt, and Hedgehog. Here, we discuss the multifaceted contribution of microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), as representative ncRNA classes, in sustaining the CSC-like traits, as well as the underlying molecular mechanisms of their action in various CSC types. 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Additional CSC features, including self-renewal and migratory and invasive capabilities, have further justified these cells as putative diagnostic, prognostic, and therapeutic targets. Given the CSC plasticity, the identification of CSC-related biomarkers has been a serious burden in CSC characterization and therapeutic targeting. Over the past decades, a compelling amount of evidence has demonstrated critical regulatory functions of non-coding RNAs (ncRNAs) on the exclusive features of CSCs. We now know that ncRNAs may interfere with signaling pathways, vital for CSC phenotype maintenance, such as Notch, Wnt, and Hedgehog. Here, we discuss the multifaceted contribution of microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), as representative ncRNA classes, in sustaining the CSC-like traits, as well as the underlying molecular mechanisms of their action in various CSC types. We further discuss the use of CSC-related ncRNAs as putative biomarkers of high diagnostic, prognostic, and therapeutic value.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32932969</pmid><doi>10.3390/ijms21186658</doi><oa>free_for_read</oa></addata></record> |
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subjects | Animals Binding sites Biology Biomarkers Biomarkers, Tumor - genetics Cancer Carcinogenesis Carcinogens Cell growth Cell self-renewal Coding Diagnostic systems Epigenetics Gene expression Humans Invasiveness Metastasis MicroRNAs MicroRNAs - genetics miRNA Molecular modelling Neoplasms - genetics Neoplasms - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Non-coding RNA Pathophysiology Phenotypes Prognosis Proteins Review RNA, Untranslated - genetics Signal transduction Signal Transduction - genetics Stem cells Therapeutic targets Wnt protein |
title | Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology |
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