Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology

The identification of cancer stem cells (CSCs) as initiators of carcinogenesis has revolutionized the era of cancer research and our perception for the disease treatment options. Additional CSC features, including self-renewal and migratory and invasive capabilities, have further justified these cel...

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Veröffentlicht in:International journal of molecular sciences 2020-09, Vol.21 (18), p.6658
Hauptverfasser: Kyriazi, Athina A, Papiris, Efstathios, Kitsos Kalyvianakis, Konstantinos, Sakellaris, George, Baritaki, Stavroula
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container_issue 18
container_start_page 6658
container_title International journal of molecular sciences
container_volume 21
creator Kyriazi, Athina A
Papiris, Efstathios
Kitsos Kalyvianakis, Konstantinos
Sakellaris, George
Baritaki, Stavroula
description The identification of cancer stem cells (CSCs) as initiators of carcinogenesis has revolutionized the era of cancer research and our perception for the disease treatment options. Additional CSC features, including self-renewal and migratory and invasive capabilities, have further justified these cells as putative diagnostic, prognostic, and therapeutic targets. Given the CSC plasticity, the identification of CSC-related biomarkers has been a serious burden in CSC characterization and therapeutic targeting. Over the past decades, a compelling amount of evidence has demonstrated critical regulatory functions of non-coding RNAs (ncRNAs) on the exclusive features of CSCs. We now know that ncRNAs may interfere with signaling pathways, vital for CSC phenotype maintenance, such as Notch, Wnt, and Hedgehog. Here, we discuss the multifaceted contribution of microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), as representative ncRNA classes, in sustaining the CSC-like traits, as well as the underlying molecular mechanisms of their action in various CSC types. We further discuss the use of CSC-related ncRNAs as putative biomarkers of high diagnostic, prognostic, and therapeutic value.
doi_str_mv 10.3390/ijms21186658
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source MEDLINE; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Animals
Binding sites
Biology
Biomarkers
Biomarkers, Tumor - genetics
Cancer
Carcinogenesis
Carcinogens
Cell growth
Cell self-renewal
Coding
Diagnostic systems
Epigenetics
Gene expression
Humans
Invasiveness
Metastasis
MicroRNAs
MicroRNAs - genetics
miRNA
Molecular modelling
Neoplasms - genetics
Neoplasms - pathology
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
Non-coding RNA
Pathophysiology
Phenotypes
Prognosis
Proteins
Review
RNA, Untranslated - genetics
Signal transduction
Signal Transduction - genetics
Stem cells
Therapeutic targets
Wnt protein
title Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology
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