Relation of High Lipoprotein (a) Concentrations to Platelet Reactivity in Individuals with and Without Coronary Artery Disease

Introduction Lipoprotein ( a ) [Lp( a )] is a risk factor for coronary artery disease (CAD). To the best of our knowledge, this is the first study addressing the relationship between Lp( a ) and platelet reactivity in primary and secondary prevention. Methods Lp( a ) was evaluated in 396 individuals with (82.3%) and without (17.7%) obstructive CAD. The population was divided into two groups according to Lp( a ) concentrations with a cutoff value of 50 mg/dL. The primary objective was to evaluate the association between Lp( a ) and adenosine diphosphate (ADP)-induced platelet reactivity using the VerifyNow™ P2Y 12 assay. Platelet reactivity was also induced by arachidonic acid and collagen–epinephrine (C-EPI) and assessed by Multiplate™, platelet function analyzer™ 100 (PFA-100), and light transmission aggregometry (LTA) assays. Secondary objectives included the assessment of the primary endpoint in individuals with or without CAD. Results Overall, 294 (74.2%) individuals had Lp( a )