RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares

Serial analysis of RNA expression in peripheral blood cells in patients with rheumatoid arthritis in remission showed changes in gene expression that precede and predict clinical flares and could provide an opportunity for intervention to prevent such flares.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2020-07, Vol.383 (3), p.218-228
Hauptverfasser:	Orange, Dana E, Yao, Vicky, Sawicka, Kirsty, Fak, John, Frank, Mayu O, Parveen, Salina, Blachere, Nathalie E, Hale, Caryn, Zhang, Fan, Raychaudhuri, Soumya, Troyanskaya, Olga G, Darnell, Robert B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology B-Lymphocytes - physiology Blood CD45 antigen Cell activation Female Fibroblasts Fibroblasts - metabolism Flow Cytometry Gene Expression Genomic analysis Humans Inflammatory diseases Laboratories Library collections Lymphocytes Lymphocytes B Male Mesenchymal Stem Cells - metabolism Mesenchyme Middle Aged Ontology Patient Acuity Patients Questionnaires Rheumatoid arthritis Ribonucleic acid RNA Sequence Analysis, RNA - methods Software packages Surveys and Questionnaires Symptom Flare Up Synovial Fluid - cytology Synovium Transcription
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Beschreibung
Zusammenfassung:	Serial analysis of RNA expression in peripheral blood cells in patients with rheumatoid arthritis in remission showed changes in gene expression that precede and predict clinical flares and could provide an opportunity for intervention to prevent such flares.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2004114