Clinical Epidemiology of Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) in Japan: Report of the COVID-19 Registry Japan

Abstract Background There is limited understanding of the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan. Methods This study included 2638 cases enrolled from 227 healthcare facilities that participated in the COVID-19 Registry Japan (COVIREGI...

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Veröffentlicht in:Clinical infectious diseases 2021-12, Vol.73 (11), p.e3677-e3689
Hauptverfasser: Matsunaga, Nobuaki, Hayakawa, Kayoko, Terada, Mari, Ohtsu, Hiroshi, Asai, Yusuke, Tsuzuki, Shinya, Suzuki, Setsuko, Toyoda, Ako, Suzuki, Kumiko, Endo, Mio, Fujii, Naoki, Suzuki, Michiyo, Saito, Sho, Uemura, Yukari, Shibata, Taro, Kondo, Masashi, Izumi, Kazuo, Terada-Hirashima, Junko, Mikami, Ayako, Sugiura, Wataru, Ohmagari, Norio
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Sprache:eng
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Zusammenfassung:Abstract Background There is limited understanding of the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan. Methods This study included 2638 cases enrolled from 227 healthcare facilities that participated in the COVID-19 Registry Japan (COVIREGI-JP). The inclusion criteria for enrollment of a case in COVIREGI-JP are both (1) a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test and (2) inpatient treatment at a healthcare facility. Results The median age of hospitalized patients with COVID-19 was 56 years (interquartile range [IQR], 40–71 years). More than half of cases were male (58.9%, 1542/2619). Nearly 60% of the cases had close contact to confirmed or suspected cases of COVID-19. The median duration of symptoms before admission was 7 days (IQR, 4–10 days). The most common comorbidities were hypertension (15%, 396/2638) and diabetes without complications (14.2%, 374/2638). The number of nonsevere cases (68.2%, n = 1798) was twice the number of severe cases (31.8%, n = 840) at admission. The respiratory support during hospitalization includes those who received no oxygen support (61.6%, 1623/2636) followed by those who received supplemental oxygen (29.9%, 788/2636) and invasive mechanical ventilation/extracorporeal membrane oxygenation (8.5%, 225/2636). Overall, 66.9% (1762/2634) of patients were discharged home, while 7.5% (197/2634) died. Conclusions We identified the clinical epidemiological features of COVID-19 in hospitalized patients in Japan. When compared with existing inpatient studies in other countries, these results demonstrated fewer comorbidities and a trend towards lower mortality. Registry data of 2638 hospitalized COVID-19 cases revealed that mechanical ventilation was required in 8.5% of cases, and the overall mortality was 7.5%. Results of this study demonstrated fewer comorbidities and lower mortality than existing inpatient studies in other countries.
ISSN:1058-4838
1537-6591
1537-6591
DOI:10.1093/cid/ciaa1470