Myoglobin for Detection of High-Risk Patients with Acute Myocarditis

There is an unmet need for accurate and practical screening to detect myocarditis. We sought to test the hypothesis that the extent of acute myocarditis, measured by late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR), can be estimated based on routine blood markers. A tota...

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Veröffentlicht in:	Journal of cardiovascular translational research 2020-10, Vol.13 (5), p.853-863
Hauptverfasser:	Kottwitz, Jan, Bruno, Katelyn A., Berg, Jan, Salomon, Gary R., Fairweather, DeLisa, Elhassan, Mawahib, Baltensperger, Nora, Kissel, Christine K., Lovrinovic, Marina, Baltensweiler, Andrea, Schmied, Christian, Templin, Christian, Lima, Joao A.C., Landmesser, Ulf, Lüscher, Thomas F., Manka, Robert, Heidecker, Bettina
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Animals Biomarkers - blood Biomedical Engineering and Bioengineering Biomedicine Cardiology Contrast Media - administration & dosage Coxsackievirus Infections - blood Coxsackievirus Infections - diagnostic imaging Coxsackievirus Infections - virology Disease Models, Animal Female Human Genetics Humans Magnetic Resonance Imaging, Cine Male Medicine Medicine & Public Health Mice, Inbred BALB C Middle Aged Myocarditis - blood Myocarditis - diagnostic imaging Myocarditis - virology Myoglobin - blood Original Original Article Predictive Value of Tests Reproducibility of Results Retrospective Studies
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Beschreibung
Zusammenfassung:	There is an unmet need for accurate and practical screening to detect myocarditis. We sought to test the hypothesis that the extent of acute myocarditis, measured by late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR), can be estimated based on routine blood markers. A total of 44 patients were diagnosed with acute myocarditis and included in this study. There was strong correlation between myoglobin and LGE (r s = 0.73 [95% CI 0.51; 0.87], p
ISSN:	1937-5387 1937-5395
DOI:	10.1007/s12265-020-09957-8