Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey
Background Because of the lack of sufficient data, we aimed to investigate the role of serum 25(OH) vitamin D level on COVID severity and related mortality. Methods This was a retrospective observational study. Data, including sociodemographic features, clinical characteristics, and laboratory data,...
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| Veröffentlicht in: | The Journal of nutrition, health & aging health & aging, 2021-02, Vol.25 (2), p.189-196 |
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| creator | Karahan, Serkan Katkat, F. |
| description | Background
Because of the lack of sufficient data, we aimed to investigate the role of serum 25(OH) vitamin D level on COVID severity and related mortality.
Methods
This was a retrospective observational study. Data, including sociodemographic features, clinical characteristics, and laboratory data, and 25(OH) vitamin D levels were recorded for each study participant. Patients were stratified into different vitamin D groups; Normal (Serum 25(OH) vitamin D level >30 ng/mL), Vitamin D insufficiency (21–29 ng/mL), and deficiency ( |
| doi_str_mv | 10.1007/s12603-020-1479-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7533663</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2484418861</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-1cfaf351cb0f8c911b66bcd138fff7b28376ce6b8fd7971190a99f5a3954506a3</originalsourceid><addsrcrecordid>eNp1kU1v1DAQhiMEoqXwA7ggS1zKITCOHX9ckKotpSstWiRKOVqO125dknixnVb773G0pXxInGzN-8w7M3qr6iWGtxiAv0u4YUBqaKDGlMsaHlWHmDOoKRficfk3pcg58IPqWUo3ALSVgj2tDgihEgMhh9W35bDVJqPg0BcbpwE17fH6_A269FkPfkSnaGVvbY_CiD6FmHXv8w6V-medvR1zQnc-X6PF-nJ5WmM5KxdT_G53z6snTvfJvrh_j6qvZx8uFuf1av1xuThZ1YZyyDU2TjvSYtOBE0Zi3DHWmQ0mwjnHu0YQzoxlnXAbLjnGErSUrtVEtrQFpslR9X7vu526wW5M2SnqXm2jH3TcqaC9-lsZ_bW6CreKt4QwRorB8b1BDD8mm7IafDK27_Vow5RUQwVwQoTABX39D3oTpjiW82aKUiwEmym8p0wMKUXrHpbBoObY1D42VWJTc2wKSs-rP6946PiVUwGaPZCKNF7Z-Hv0_11_AsZmoHM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2484418861</pqid></control><display><type>article</type><title>Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>SpringerLink Journals - AutoHoldings</source><creator>Karahan, Serkan ; Katkat, F.</creator><creatorcontrib>Karahan, Serkan ; Katkat, F.</creatorcontrib><description>Background
Because of the lack of sufficient data, we aimed to investigate the role of serum 25(OH) vitamin D level on COVID severity and related mortality.
Methods
This was a retrospective observational study. Data, including sociodemographic features, clinical characteristics, and laboratory data, and 25(OH) vitamin D levels were recorded for each study participant. Patients were stratified into different vitamin D groups; Normal (Serum 25(OH) vitamin D level >30 ng/mL), Vitamin D insufficiency (21–29 ng/mL), and deficiency (<20 ng/ mL). The severity of COVID was classified according to the Chinese Clinical Guideline for classification of COVID-19 severity. Mortality data were determined for participants. Univariate and multivariate Logistic regression analysis was performed to determine independent predictors of in-hospital mortality.
Results
Overall, 149 COVID-19 patients (females 45.6%, mean age 63.5 ± 15.3 (range 24–90 years) years) were included. Forty-seven patients (31.5%) had moderate COVID-19, whereas 102 patients (68.5%) had severe-critical COVID-19. The mean 25(OH) vitamin D level was 15.2 ± 10.3 ng/mL. Thirty-four (22.8%) and 103 (69.1%) patients had vitamin D insufficiency and deficiency, respectively. Mean serum 25(OH) vitamin D level was significantly lower in patients with severe-critical COVID-19 compared with moderate COVID-19 (10.1 ± 6.2 vs. 26.3 ± 8.4 ng/mL, respectively, p<0.001). Vitamin D insufficiency was present in 93.1% of the patients with severe-critical COVID-19. Multivariate logistic regression analysis revealed that only lymphocyte count, white blood cell count, serum albumin and, 25(OH) vitamin D level were independent predictors of mortality.
Conclusion
Serum 25(OH) vitamin D was independently associated with mortality in COVID-19 patients.</description><identifier>ISSN: 1279-7707</identifier><identifier>EISSN: 1760-4788</identifier><identifier>DOI: 10.1007/s12603-020-1479-0</identifier><identifier>PMID: 33491033</identifier><language>eng</language><publisher>Paris: Springer Paris</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aging ; Clinical practice guidelines ; Coronaviruses ; COVID-19 ; COVID-19 - blood ; COVID-19 - mortality ; COVID-19 - virology ; COVID-19 Drug Treatment ; Female ; Geriatrics/Gerontology ; Humans ; Logistic Models ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; Neurosciences ; Nutrition ; Pandemics ; Primary Care Medicine ; Quality of Life Research ; Regression analysis ; Retrospective Studies ; SARS-CoV-2 - isolation & purification ; Turkey - epidemiology ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - mortality ; Vitamin D Deficiency - virology ; Young Adult</subject><ispartof>The Journal of nutrition, health & aging, 2021-02, Vol.25 (2), p.189-196</ispartof><rights>Serdi and Springer-Verlag International SAS, part of Springer Nature 2020</rights><rights>Serdi and Springer-Verlag International SAS, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-1cfaf351cb0f8c911b66bcd138fff7b28376ce6b8fd7971190a99f5a3954506a3</citedby><cites>FETCH-LOGICAL-c470t-1cfaf351cb0f8c911b66bcd138fff7b28376ce6b8fd7971190a99f5a3954506a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12603-020-1479-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12603-020-1479-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33491033$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karahan, Serkan</creatorcontrib><creatorcontrib>Katkat, F.</creatorcontrib><title>Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey</title><title>The Journal of nutrition, health & aging</title><addtitle>J Nutr Health Aging</addtitle><addtitle>J Nutr Health Aging</addtitle><description>Background
Because of the lack of sufficient data, we aimed to investigate the role of serum 25(OH) vitamin D level on COVID severity and related mortality.
Methods
This was a retrospective observational study. Data, including sociodemographic features, clinical characteristics, and laboratory data, and 25(OH) vitamin D levels were recorded for each study participant. Patients were stratified into different vitamin D groups; Normal (Serum 25(OH) vitamin D level >30 ng/mL), Vitamin D insufficiency (21–29 ng/mL), and deficiency (<20 ng/ mL). The severity of COVID was classified according to the Chinese Clinical Guideline for classification of COVID-19 severity. Mortality data were determined for participants. Univariate and multivariate Logistic regression analysis was performed to determine independent predictors of in-hospital mortality.
Results
Overall, 149 COVID-19 patients (females 45.6%, mean age 63.5 ± 15.3 (range 24–90 years) years) were included. Forty-seven patients (31.5%) had moderate COVID-19, whereas 102 patients (68.5%) had severe-critical COVID-19. The mean 25(OH) vitamin D level was 15.2 ± 10.3 ng/mL. Thirty-four (22.8%) and 103 (69.1%) patients had vitamin D insufficiency and deficiency, respectively. Mean serum 25(OH) vitamin D level was significantly lower in patients with severe-critical COVID-19 compared with moderate COVID-19 (10.1 ± 6.2 vs. 26.3 ± 8.4 ng/mL, respectively, p<0.001). Vitamin D insufficiency was present in 93.1% of the patients with severe-critical COVID-19. Multivariate logistic regression analysis revealed that only lymphocyte count, white blood cell count, serum albumin and, 25(OH) vitamin D level were independent predictors of mortality.
Conclusion
Serum 25(OH) vitamin D was independently associated with mortality in COVID-19 patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Clinical practice guidelines</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - blood</subject><subject>COVID-19 - mortality</subject><subject>COVID-19 - virology</subject><subject>COVID-19 Drug Treatment</subject><subject>Female</subject><subject>Geriatrics/Gerontology</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neurosciences</subject><subject>Nutrition</subject><subject>Pandemics</subject><subject>Primary Care Medicine</subject><subject>Quality of Life Research</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>SARS-CoV-2 - isolation & purification</subject><subject>Turkey - epidemiology</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - mortality</subject><subject>Vitamin D Deficiency - virology</subject><subject>Young Adult</subject><issn>1279-7707</issn><issn>1760-4788</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU1v1DAQhiMEoqXwA7ggS1zKITCOHX9ckKotpSstWiRKOVqO125dknixnVb773G0pXxInGzN-8w7M3qr6iWGtxiAv0u4YUBqaKDGlMsaHlWHmDOoKRficfk3pcg58IPqWUo3ALSVgj2tDgihEgMhh9W35bDVJqPg0BcbpwE17fH6_A269FkPfkSnaGVvbY_CiD6FmHXv8w6V-medvR1zQnc-X6PF-nJ5WmM5KxdT_G53z6snTvfJvrh_j6qvZx8uFuf1av1xuThZ1YZyyDU2TjvSYtOBE0Zi3DHWmQ0mwjnHu0YQzoxlnXAbLjnGErSUrtVEtrQFpslR9X7vu526wW5M2SnqXm2jH3TcqaC9-lsZ_bW6CreKt4QwRorB8b1BDD8mm7IafDK27_Vow5RUQwVwQoTABX39D3oTpjiW82aKUiwEmym8p0wMKUXrHpbBoObY1D42VWJTc2wKSs-rP6946PiVUwGaPZCKNF7Z-Hv0_11_AsZmoHM</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Karahan, Serkan</creator><creator>Katkat, F.</creator><general>Springer Paris</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210201</creationdate><title>Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey</title><author>Karahan, Serkan ; Katkat, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-1cfaf351cb0f8c911b66bcd138fff7b28376ce6b8fd7971190a99f5a3954506a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Clinical practice guidelines</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - blood</topic><topic>COVID-19 - mortality</topic><topic>COVID-19 - virology</topic><topic>COVID-19 Drug Treatment</topic><topic>Female</topic><topic>Geriatrics/Gerontology</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neurosciences</topic><topic>Nutrition</topic><topic>Pandemics</topic><topic>Primary Care Medicine</topic><topic>Quality of Life Research</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>SARS-CoV-2 - isolation & purification</topic><topic>Turkey - epidemiology</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - mortality</topic><topic>Vitamin D Deficiency - virology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karahan, Serkan</creatorcontrib><creatorcontrib>Katkat, F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of nutrition, health & aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karahan, Serkan</au><au>Katkat, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey</atitle><jtitle>The Journal of nutrition, health & aging</jtitle><stitle>J Nutr Health Aging</stitle><addtitle>J Nutr Health Aging</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>25</volume><issue>2</issue><spage>189</spage><epage>196</epage><pages>189-196</pages><issn>1279-7707</issn><eissn>1760-4788</eissn><abstract>Background
Because of the lack of sufficient data, we aimed to investigate the role of serum 25(OH) vitamin D level on COVID severity and related mortality.
Methods
This was a retrospective observational study. Data, including sociodemographic features, clinical characteristics, and laboratory data, and 25(OH) vitamin D levels were recorded for each study participant. Patients were stratified into different vitamin D groups; Normal (Serum 25(OH) vitamin D level >30 ng/mL), Vitamin D insufficiency (21–29 ng/mL), and deficiency (<20 ng/ mL). The severity of COVID was classified according to the Chinese Clinical Guideline for classification of COVID-19 severity. Mortality data were determined for participants. Univariate and multivariate Logistic regression analysis was performed to determine independent predictors of in-hospital mortality.
Results
Overall, 149 COVID-19 patients (females 45.6%, mean age 63.5 ± 15.3 (range 24–90 years) years) were included. Forty-seven patients (31.5%) had moderate COVID-19, whereas 102 patients (68.5%) had severe-critical COVID-19. The mean 25(OH) vitamin D level was 15.2 ± 10.3 ng/mL. Thirty-four (22.8%) and 103 (69.1%) patients had vitamin D insufficiency and deficiency, respectively. Mean serum 25(OH) vitamin D level was significantly lower in patients with severe-critical COVID-19 compared with moderate COVID-19 (10.1 ± 6.2 vs. 26.3 ± 8.4 ng/mL, respectively, p<0.001). Vitamin D insufficiency was present in 93.1% of the patients with severe-critical COVID-19. Multivariate logistic regression analysis revealed that only lymphocyte count, white blood cell count, serum albumin and, 25(OH) vitamin D level were independent predictors of mortality.
Conclusion
Serum 25(OH) vitamin D was independently associated with mortality in COVID-19 patients.</abstract><cop>Paris</cop><pub>Springer Paris</pub><pmid>33491033</pmid><doi>10.1007/s12603-020-1479-0</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1279-7707 |
| ispartof | The Journal of nutrition, health & aging, 2021-02, Vol.25 (2), p.189-196 |
| issn | 1279-7707 1760-4788 |
| language | eng |
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| subjects | Adult Aged Aged, 80 and over Aging Clinical practice guidelines Coronaviruses COVID-19 COVID-19 - blood COVID-19 - mortality COVID-19 - virology COVID-19 Drug Treatment Female Geriatrics/Gerontology Humans Logistic Models Male Medical prognosis Medicine Medicine & Public Health Middle Aged Mortality Neurosciences Nutrition Pandemics Primary Care Medicine Quality of Life Research Regression analysis Retrospective Studies SARS-CoV-2 - isolation & purification Turkey - epidemiology Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - mortality Vitamin D Deficiency - virology Young Adult |
| title | Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey |
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