Association of the H2FPEF Risk Score with Recurrence of Atrial Fibrillation Following Pulmonary Vein Isolation

BACKGROUNDWhile atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) commonly coexist, the efficacy of pulmonary vein isolation in the setting of HFpEF is unclear. METHODSIn a cohort of patients who underwent cryoballoon ablation (CBA) from 2011 to 2016, we calculated the H2FPEF risk score, a novel 6-item score (scale: 0-9 points) that accurately predicts the probability of HFpEF. We compared characteristics of patients by H2FPEF score and evaluated the association of H2FPEF score with 12-month recurrence of AF post-procedure. RESULTSOf patients with available data to calculate the H2FPEF score (n=105), the median H2FPEF score was 5 (interquartile range: 4-6), corresponding to >80% probability of HFpEF. Compared to patients with H2FPEF scores ≤4 (n=34), patients with H2FPEF scores of 5 and 6 (n=46) and ≥7 (n=25) carried higher rates of hypertension (≤4: 21% vs. 5 and 6: 63% vs. ≥7: 88%, P