Associated of rs895819 with risk of cervical cancer in Chinese women

The results also indicated differential effects of rs895819 on cervical cancer risk between two studies, and in both homogenous and additive models, the effects were controversial when significant associations were found in both studies (Data on forest plots not shown). [...]the findings were inconsistent between these two studies. Table 1 Synthesis analysis of the association between rs895819 and cervical cancer risk Quantitative synthesis n a Heterogenous Homogenous Dominant Recessive Additive OR (95% CI) b P c OR (95% CI) b P c OR (95% CI) b P c OR (95% CI) b P c OR (95% CI)b P c Analysis 1d 2 0.79 (0.44-1.42) 0.039 1.13 (0.18-7.26) < 0.001 0.86 (0.38-1.93) 0.002 0.47 (0.27-0.82) 0.294 0.94 (0.40-2.19) < 0.001 Analysis 2e 2 0.71 (0.20-2.52) 0.015 0.88 (0.14-5.65) < 0.001 0.83 (0.16-4.32) 0.001 1.17 (0.52-2.63) 0.002 1.06 (0.46-2.48) < 0.001 a Number of comparisons. b The crude OR and 95% CI were calculated based on the genotype frequencies. c P value of Q-test for heterogeneity analysis. d The genetic variant comparisons in Analysis 1 were TC versus TT, CC versus TT, TC/CC versus TT, CC versus TT/TC and C versus T for heterogenous, homogenous, dominant, recessive and additive model respectively. e The genetic variant comparisons in Analysis 2 were TC versus CC, TT versus CC, TC/TT versus CC, TT versus CC/TC and T versus C for heterogenous, homogenous, dominant, recessive and additive model respectively. In the study by Xiong et al [2], a more pronounced reduction in cervical cancer risk was observed among clinical stage I patients and squamous cell carcinoma patients carrying rs895819 CT or TT genotypes when comparing with CC genotypes.