Antigenic Fingerprinting of Respiratory Syncytial Virus (RSV)-A–Infected Hematopoietic Cell Transplant Recipients Reveals Importance of Mucosal Anti–RSV G Antibodies in Control of RSV Infection in Humans

Abstract Background Respiratory syncytial virus (RSV) infection causes significant morbidity in hematopoietic cell transplant (HCT) recipients. However, antibody responses that correlate with recovery from RSV disease are not fully understood. Methods In this study, antibody repertoire in paired ser...

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Veröffentlicht in:	The Journal of infectious diseases 2020-02, Vol.221 (4), p.636-646
Hauptverfasser:	Fuentes, Sandra, Hahn, Megan, Chilcote, Katarina, Chemaly, Roy F, Shah, Dimpy P, Ye, Xunyan, Avadhanula, Vasanthi, Piedra, Pedro A, Golding, Hana, Khurana, Surender
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Avidity Fingerprinting Infections Major and Brief Reports Morbidity Mucosa Phage display Respiratory syncytial virus Respiratory tract Stem cell transplantation Surface plasmon resonance
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Zusammenfassung:	Abstract Background Respiratory syncytial virus (RSV) infection causes significant morbidity in hematopoietic cell transplant (HCT) recipients. However, antibody responses that correlate with recovery from RSV disease are not fully understood. Methods In this study, antibody repertoire in paired serum and nasal wash samples from acutely RSV-A–infected HCT recipients who recovered early (
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/jiz608