CT features and disease spread patterns in ROS1-rearranged lung adenocarcinomas: comparison with those of EGFR-mutant or ALK-rearranged lung adenocarcinomas

The purpose of this study was to investigate the differences in CT characteristics and disease spread patterns between ROS1 -rearranged adenocarcinomas and epidermal growth factor receptor ( EGFR )-mutant or anaplastic lymphoma kinase ( ALK )-rearranged adenocarcinomas. Patients with stage IIIb/IV adenocarcinoma with ROS1 rearrangement, EGFR mutations, or ALK rearrangement were retrospectively identified. Two radiologists evaluated CT features and disease spread patterns. A multivariable logistic regression model was applied to determine the clinical and CT characteristics that can discriminate between ROS1 -rearranged and EGFR -mutant or ALK -rearranged adenocarcinomas. A cohort of 169 patients was identified ( ROS1 = 23, EGFR = 120, and ALK = 26). Compared to EGFR -mutant adenocarcinomas, ROS1 -rearranged adenocarcinomas were less likely to have air-bronchogram (p = 0.011) and pleural retraction (p = 0.048) and more likely to have pleural effusion (p = 0.025), pericardial metastases (p