Candidate gene mapping identifies genomic variations in the fire blight susceptibility genes HIPM and DIPM across the Malus germplasm

Development of apple ( Malus domestica ) cultivars resistant to fire blight, a devastating bacterial disease caused by Erwinia amylovora, is a priority for apple breeding programs. Towards this goal, the inactivation of members of the HIPM and DIPM gene families with a role in fire blight susceptibi...

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Veröffentlicht in:	Scientific reports 2020-10, Vol.10 (1), p.16317-16317, Article 16317
Hauptverfasser:	Tegtmeier, Richard, Pompili, Valerio, Singh, Jugpreet, Micheletti, Diego, Silva, Katchen Julliany Pereira, Malnoy, Mickael, Khan, Awais
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208 631/208/207 631/208/2491 631/208/480 631/208/711 631/208/721 631/208/727 631/208/8 631/449/711 Apples Bacterial diseases Biotechnology Blight Chromosome Mapping - methods Cultivars Disease resistance Disease Resistance - genetics Erwinia amylovora Fruits Gene families Gene mapping Genes Genes, Plant - genetics Genetic diversity Genetic Predisposition to Disease - genetics Genetic Variation - genetics Genotyping Techniques Germplasm Humanities and Social Sciences Inactivation Malus - genetics Malus - immunology Malus - microbiology Malus domestica multidisciplinary Plant Breeding Plant Diseases - immunology Plant Diseases - microbiology Polymorphism, Single Nucleotide - genetics Science Science (multidisciplinary) Seed Bank Sequence Analysis, DNA Single-nucleotide polymorphism Susceptibility
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Zusammenfassung:	Development of apple ( Malus domestica ) cultivars resistant to fire blight, a devastating bacterial disease caused by Erwinia amylovora, is a priority for apple breeding programs. Towards this goal, the inactivation of members of the HIPM and DIPM gene families with a role in fire blight susceptibility ( S genes) can help achieve sustainable tolerance. We have investigated the genomic diversity of HIPM and DIPM genes in Malus germplasm collections and used a candidate gene-based association mapping approach to identify SNPs (single nucleotide polymorphisms) with significant associations to fire blight susceptibility. A total of 87 unique SNP variants were identified in HIPM and DIPM genes across 93 Malus accessions. Thirty SNPs showed significant associations ( p
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-020-73284-w