Genomic analysis reveals high virulence and antibiotic resistance amongst phage susceptible Acinetobacter baumannii

In this study, we examined the association between antimicrobial resistance, CRISPR/Cas systems and virulence with phage susceptibility in Acinetobacter baumannii and investigated draft genomes of phage susceptible multidrug resistant A. baumannii strains from Thailand. We investigated 230 A. bauman...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2020-09, Vol.10 (1), p.16154-16154, Article 16154
Hauptverfasser:	Leungtongkam, Udomluk, Thummeepak, Rapee, Kitti, Thawatchai, Tasanapak, Kannipa, Wongwigkarn, Jintana, Styles, Kathryn M., Wellington, Elizabeth M. H., Millard, Andrew D., Sagona, Antonia P., Sitthisak, Sutthirat
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208 631/326 Acinetobacter baumannii Acinetobacter baumannii - drug effects Acinetobacter baumannii - genetics Acinetobacter Infections - microbiology Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics Antimicrobial resistance Bacteriophages Biofilms Biofilms - drug effects Coevolution CRISPR Drug resistance Drug Resistance, Bacterial - genetics Genome, Bacterial Genomes Genomic analysis Humanities and Social Sciences multidisciplinary Multidrug resistance OmpA protein Phages Prophages Science Science (multidisciplinary) Strains (organisms) Virulence
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In this study, we examined the association between antimicrobial resistance, CRISPR/Cas systems and virulence with phage susceptibility in Acinetobacter baumannii and investigated draft genomes of phage susceptible multidrug resistant A. baumannii strains from Thailand. We investigated 230 A. baumannii strains using 17 lytic A. baumannii phages and the phage susceptibility was 46.5% (107/230). Phage susceptibility was also associated with resistance to numerous antibiotics ( p -value
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-020-73123-y