Significance of Lymphovascular Space Invasion by the Sarcomatous Component in Uterine Carcinosarcoma
Objective The aim of this study was to examine the significance of lymphovascular space invasion (LVSI) with a sarcomatous component on the tumor characteristics and clinical outcomes of women with uterine carcinosarcoma (UCS). Methods This was a secondary analysis of a prior multicenter retrospecti...
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| Veröffentlicht in: | Annals of surgical oncology 2018-09, Vol.25 (9), p.2756-2766 |
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| creator | Matsuo, Koji Takazawa, Yutaka Ross, Malcolm S. Elishaev, Esther Yunokawa, Mayu Sheridan, Todd B. Bush, Stephen H. Klobocista, Merieme M. Blake, Erin A. Takano, Tadao Baba, Tsukasa Satoh, Shinya Shida, Masako Ikeda, Yuji Adachi, Sosuke Yokoyama, Takuhei Takekuma, Munetaka Yanai, Shiori Takeuchi, Satoshi Nishimura, Masato Iwasaki, Keita Johnson, Marian S. Yoshida, Masayuki Hakam, Ardeshir Machida, Hiroko Mhawech-Fauceglia, Paulette Ueda, Yutaka Yoshino, Kiyoshi Kajiwara, Hiroshi Hasegawa, Kosei Yasuda, Masanori Miyake, Takahito M. Moriya, Takuya Yuba, Yoshiaki Morgan, Terry Fukagawa, Tomoyuki Pejovic, Tanja Nagano, Tadayoshi Sasaki, Takeshi Richmond, Abby M. Post, Miriam D. Shahzad, Mian M. K. Im, Dwight D. Yoshida, Hiroshi Enomoto, Takayuki Omatsu, Kohei Ueland, Frederick R. Kelley, Joseph L. Karabakhtsian, Rouzan G. Roman, Lynda D. |
| description | Objective
The aim of this study was to examine the significance of lymphovascular space invasion (LVSI) with a sarcomatous component on the tumor characteristics and clinical outcomes of women with uterine carcinosarcoma (UCS).
Methods
This was a secondary analysis of a prior multicenter retrospective study that examined women with stage I–IV UCS who underwent primary hysterectomy. Archived histopathology slides were reviewed and LVSI was scored as follows: LVSI with a carcinomatous component alone (LVSI-carcinoma;
n
= 375, 76.8%) or LVSI containing a sarcomatous component with or without a carcinomatous component (LVSI-sarcoma;
n
= 113, 23.2%). Qualitative metrics of LVSI were correlated to clinicopathological factors and survival outcome.
Results
Tumors in the LVSI-sarcoma group were more likely to have sarcoma dominance (82.1 vs. 26.4%) heterologous sarcomatous component (51.3 vs. 37.9%), low-grade carcinoma (42.5 vs. 22.4%), and large tumor size (81.0 vs. 70.2%) in the primary tumor site compared with tumors in the LVSI-carcinoma group (all
p
|
| doi_str_mv | 10.1245/s10434-018-6547-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7523233</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2064249966</sourcerecordid><originalsourceid>FETCH-LOGICAL-c536t-ffa21fc40c3685887c45d06dd6e8411ca11054852d7ddf6cb16d96a1bdf45d783</originalsourceid><addsrcrecordid>eNp1kU1r3DAQhk1padKkP6CXIuilFzcaWV--FMqSNoGFHLY5C60k7yrYkivZIfvvo8VJ-gE9Scw88868vFX1AfAXIJRdZMC0oTUGWXNGRf3wqjoFViqUS3hd_pjLuiWcnVTvcr7DGESD2dvqhLStAC7EaWU3fhd8540OxqHYofVhGPfxXmcz9zqhzahL_TqUgo8BbQ9o2ju00cnEQU9xzmgVhzEGFybkA7qdXPLBoVUBfIh54c6rN53us3v_9J5Vt98vf66u6vXNj-vVt3VtWMOnuus0gc5QbBoumZTCUGYxt5Y7SQGMBsCMSkassLbjZgvctlzD1nYFFLI5q74uuuO8HZw15aikezUmP-h0UFF79Xcn-L3axXslGGlI0xSBz08CKf6aXZ7U4LNxfa-DK14VwZwS2racF_TTP-hdnFMo9o5Uw0ByBoWChTIp5pxc93IMYHXMUC0ZqpKhOmaoHsrMxz9dvEw8h1YAsgC5tMLOpd-r_6_6CGwOqew</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2063518651</pqid></control><display><type>article</type><title>Significance of Lymphovascular Space Invasion by the Sarcomatous Component in Uterine Carcinosarcoma</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Matsuo, Koji ; Takazawa, Yutaka ; Ross, Malcolm S. ; Elishaev, Esther ; Yunokawa, Mayu ; Sheridan, Todd B. ; Bush, Stephen H. ; Klobocista, Merieme M. ; Blake, Erin A. ; Takano, Tadao ; Baba, Tsukasa ; Satoh, Shinya ; Shida, Masako ; Ikeda, Yuji ; Adachi, Sosuke ; Yokoyama, Takuhei ; Takekuma, Munetaka ; Yanai, Shiori ; Takeuchi, Satoshi ; Nishimura, Masato ; Iwasaki, Keita ; Johnson, Marian S. ; Yoshida, Masayuki ; Hakam, Ardeshir ; Machida, Hiroko ; Mhawech-Fauceglia, Paulette ; Ueda, Yutaka ; Yoshino, Kiyoshi ; Kajiwara, Hiroshi ; Hasegawa, Kosei ; Yasuda, Masanori ; Miyake, Takahito M. ; Moriya, Takuya ; Yuba, Yoshiaki ; Morgan, Terry ; Fukagawa, Tomoyuki ; Pejovic, Tanja ; Nagano, Tadayoshi ; Sasaki, Takeshi ; Richmond, Abby M. ; Post, Miriam D. ; Shahzad, Mian M. K. ; Im, Dwight D. ; Yoshida, Hiroshi ; Enomoto, Takayuki ; Omatsu, Kohei ; Ueland, Frederick R. ; Kelley, Joseph L. ; Karabakhtsian, Rouzan G. ; Roman, Lynda D.</creator><creatorcontrib>Matsuo, Koji ; Takazawa, Yutaka ; Ross, Malcolm S. ; Elishaev, Esther ; Yunokawa, Mayu ; Sheridan, Todd B. ; Bush, Stephen H. ; Klobocista, Merieme M. ; Blake, Erin A. ; Takano, Tadao ; Baba, Tsukasa ; Satoh, Shinya ; Shida, Masako ; Ikeda, Yuji ; Adachi, Sosuke ; Yokoyama, Takuhei ; Takekuma, Munetaka ; Yanai, Shiori ; Takeuchi, Satoshi ; Nishimura, Masato ; Iwasaki, Keita ; Johnson, Marian S. ; Yoshida, Masayuki ; Hakam, Ardeshir ; Machida, Hiroko ; Mhawech-Fauceglia, Paulette ; Ueda, Yutaka ; Yoshino, Kiyoshi ; Kajiwara, Hiroshi ; Hasegawa, Kosei ; Yasuda, Masanori ; Miyake, Takahito M. ; Moriya, Takuya ; Yuba, Yoshiaki ; Morgan, Terry ; Fukagawa, Tomoyuki ; Pejovic, Tanja ; Nagano, Tadayoshi ; Sasaki, Takeshi ; Richmond, Abby M. ; Post, Miriam D. ; Shahzad, Mian M. K. ; Im, Dwight D. ; Yoshida, Hiroshi ; Enomoto, Takayuki ; Omatsu, Kohei ; Ueland, Frederick R. ; Kelley, Joseph L. ; Karabakhtsian, Rouzan G. ; Roman, Lynda D.</creatorcontrib><description>Objective
The aim of this study was to examine the significance of lymphovascular space invasion (LVSI) with a sarcomatous component on the tumor characteristics and clinical outcomes of women with uterine carcinosarcoma (UCS).
Methods
This was a secondary analysis of a prior multicenter retrospective study that examined women with stage I–IV UCS who underwent primary hysterectomy. Archived histopathology slides were reviewed and LVSI was scored as follows: LVSI with a carcinomatous component alone (LVSI-carcinoma;
n
= 375, 76.8%) or LVSI containing a sarcomatous component with or without a carcinomatous component (LVSI-sarcoma;
n
= 113, 23.2%). Qualitative metrics of LVSI were correlated to clinicopathological factors and survival outcome.
Results
Tumors in the LVSI-sarcoma group were more likely to have sarcoma dominance (82.1 vs. 26.4%) heterologous sarcomatous component (51.3 vs. 37.9%), low-grade carcinoma (42.5 vs. 22.4%), and large tumor size (81.0 vs. 70.2%) in the primary tumor site compared with tumors in the LVSI-carcinoma group (all
p
< 0.05). On multivariate analysis, LVSI-sarcoma was independently associated with decreased progression-free survival (5-year rates: 34.9 vs. 40.8%, adjusted hazard ratio [HR] 1.84, 95% confidence interval [CI] 1.36–2.50,
p
< 0.001), and cause-specific survival (5-year rates: 41.8 vs. 55.9%, adjusted HR 1.95, 95% CI 1.39–2.75,
p
< 0.001) compared with LVSI-carcinoma. Postoperative radiotherapy for women with LVSI-sarcoma had a higher reduction rate of recurrence/progression of disease (54% reduction,
p
= 0.04) compared with postoperative radiotherapy for women with LVSI-carcinoma (26% reduction,
p
= 0.08).
Conclusion
In UCS, the presence of a sarcomatous component in LVSI is particularly prevalent when a tumor has sarcoma dominance. Our study suggests that LVSI containing a sarcomatous component may be a predictor of decreased survival for women with UCS.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-018-6547-x</identifier><identifier>PMID: 29971677</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Blood Vessels - pathology ; Carcinosarcoma - pathology ; Carcinosarcoma - therapy ; Chemotherapy, Adjuvant ; Disease Progression ; Dominance ; Female ; Gynecologic Oncology ; Humans ; Hysterectomy ; Lymphatic Metastasis ; Lymphatic Vessels - pathology ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate analysis ; Neoplasm Invasiveness ; Oncology ; Progression-Free Survival ; Radiation therapy ; Radiotherapy, Adjuvant ; Retrospective Studies ; Sarcoma ; Surgery ; Surgical Oncology ; Survival ; Survival Rate ; Tumors ; Uterine Neoplasms - pathology ; Uterine Neoplasms - therapy ; Uterus</subject><ispartof>Annals of surgical oncology, 2018-09, Vol.25 (9), p.2756-2766</ispartof><rights>Society of Surgical Oncology 2018</rights><rights>Annals of Surgical Oncology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-ffa21fc40c3685887c45d06dd6e8411ca11054852d7ddf6cb16d96a1bdf45d783</citedby><cites>FETCH-LOGICAL-c536t-ffa21fc40c3685887c45d06dd6e8411ca11054852d7ddf6cb16d96a1bdf45d783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-018-6547-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-018-6547-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29971677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsuo, Koji</creatorcontrib><creatorcontrib>Takazawa, Yutaka</creatorcontrib><creatorcontrib>Ross, Malcolm S.</creatorcontrib><creatorcontrib>Elishaev, Esther</creatorcontrib><creatorcontrib>Yunokawa, Mayu</creatorcontrib><creatorcontrib>Sheridan, Todd B.</creatorcontrib><creatorcontrib>Bush, Stephen H.</creatorcontrib><creatorcontrib>Klobocista, Merieme M.</creatorcontrib><creatorcontrib>Blake, Erin A.</creatorcontrib><creatorcontrib>Takano, Tadao</creatorcontrib><creatorcontrib>Baba, Tsukasa</creatorcontrib><creatorcontrib>Satoh, Shinya</creatorcontrib><creatorcontrib>Shida, Masako</creatorcontrib><creatorcontrib>Ikeda, Yuji</creatorcontrib><creatorcontrib>Adachi, Sosuke</creatorcontrib><creatorcontrib>Yokoyama, Takuhei</creatorcontrib><creatorcontrib>Takekuma, Munetaka</creatorcontrib><creatorcontrib>Yanai, Shiori</creatorcontrib><creatorcontrib>Takeuchi, Satoshi</creatorcontrib><creatorcontrib>Nishimura, Masato</creatorcontrib><creatorcontrib>Iwasaki, Keita</creatorcontrib><creatorcontrib>Johnson, Marian S.</creatorcontrib><creatorcontrib>Yoshida, Masayuki</creatorcontrib><creatorcontrib>Hakam, Ardeshir</creatorcontrib><creatorcontrib>Machida, Hiroko</creatorcontrib><creatorcontrib>Mhawech-Fauceglia, Paulette</creatorcontrib><creatorcontrib>Ueda, Yutaka</creatorcontrib><creatorcontrib>Yoshino, Kiyoshi</creatorcontrib><creatorcontrib>Kajiwara, Hiroshi</creatorcontrib><creatorcontrib>Hasegawa, Kosei</creatorcontrib><creatorcontrib>Yasuda, Masanori</creatorcontrib><creatorcontrib>Miyake, Takahito M.</creatorcontrib><creatorcontrib>Moriya, Takuya</creatorcontrib><creatorcontrib>Yuba, Yoshiaki</creatorcontrib><creatorcontrib>Morgan, Terry</creatorcontrib><creatorcontrib>Fukagawa, Tomoyuki</creatorcontrib><creatorcontrib>Pejovic, Tanja</creatorcontrib><creatorcontrib>Nagano, Tadayoshi</creatorcontrib><creatorcontrib>Sasaki, Takeshi</creatorcontrib><creatorcontrib>Richmond, Abby M.</creatorcontrib><creatorcontrib>Post, Miriam D.</creatorcontrib><creatorcontrib>Shahzad, Mian M. K.</creatorcontrib><creatorcontrib>Im, Dwight D.</creatorcontrib><creatorcontrib>Yoshida, Hiroshi</creatorcontrib><creatorcontrib>Enomoto, Takayuki</creatorcontrib><creatorcontrib>Omatsu, Kohei</creatorcontrib><creatorcontrib>Ueland, Frederick R.</creatorcontrib><creatorcontrib>Kelley, Joseph L.</creatorcontrib><creatorcontrib>Karabakhtsian, Rouzan G.</creatorcontrib><creatorcontrib>Roman, Lynda D.</creatorcontrib><title>Significance of Lymphovascular Space Invasion by the Sarcomatous Component in Uterine Carcinosarcoma</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Objective
The aim of this study was to examine the significance of lymphovascular space invasion (LVSI) with a sarcomatous component on the tumor characteristics and clinical outcomes of women with uterine carcinosarcoma (UCS).
Methods
This was a secondary analysis of a prior multicenter retrospective study that examined women with stage I–IV UCS who underwent primary hysterectomy. Archived histopathology slides were reviewed and LVSI was scored as follows: LVSI with a carcinomatous component alone (LVSI-carcinoma;
n
= 375, 76.8%) or LVSI containing a sarcomatous component with or without a carcinomatous component (LVSI-sarcoma;
n
= 113, 23.2%). Qualitative metrics of LVSI were correlated to clinicopathological factors and survival outcome.
Results
Tumors in the LVSI-sarcoma group were more likely to have sarcoma dominance (82.1 vs. 26.4%) heterologous sarcomatous component (51.3 vs. 37.9%), low-grade carcinoma (42.5 vs. 22.4%), and large tumor size (81.0 vs. 70.2%) in the primary tumor site compared with tumors in the LVSI-carcinoma group (all
p
< 0.05). On multivariate analysis, LVSI-sarcoma was independently associated with decreased progression-free survival (5-year rates: 34.9 vs. 40.8%, adjusted hazard ratio [HR] 1.84, 95% confidence interval [CI] 1.36–2.50,
p
< 0.001), and cause-specific survival (5-year rates: 41.8 vs. 55.9%, adjusted HR 1.95, 95% CI 1.39–2.75,
p
< 0.001) compared with LVSI-carcinoma. Postoperative radiotherapy for women with LVSI-sarcoma had a higher reduction rate of recurrence/progression of disease (54% reduction,
p
= 0.04) compared with postoperative radiotherapy for women with LVSI-carcinoma (26% reduction,
p
= 0.08).
Conclusion
In UCS, the presence of a sarcomatous component in LVSI is particularly prevalent when a tumor has sarcoma dominance. Our study suggests that LVSI containing a sarcomatous component may be a predictor of decreased survival for women with UCS.</description><subject>Blood Vessels - pathology</subject><subject>Carcinosarcoma - pathology</subject><subject>Carcinosarcoma - therapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Disease Progression</subject><subject>Dominance</subject><subject>Female</subject><subject>Gynecologic Oncology</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Lymphatic Metastasis</subject><subject>Lymphatic Vessels - pathology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Neoplasm Invasiveness</subject><subject>Oncology</subject><subject>Progression-Free Survival</subject><subject>Radiation therapy</subject><subject>Radiotherapy, Adjuvant</subject><subject>Retrospective Studies</subject><subject>Sarcoma</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Tumors</subject><subject>Uterine Neoplasms - pathology</subject><subject>Uterine Neoplasms - therapy</subject><subject>Uterus</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1r3DAQhk1padKkP6CXIuilFzcaWV--FMqSNoGFHLY5C60k7yrYkivZIfvvo8VJ-gE9Scw88868vFX1AfAXIJRdZMC0oTUGWXNGRf3wqjoFViqUS3hd_pjLuiWcnVTvcr7DGESD2dvqhLStAC7EaWU3fhd8540OxqHYofVhGPfxXmcz9zqhzahL_TqUgo8BbQ9o2ju00cnEQU9xzmgVhzEGFybkA7qdXPLBoVUBfIh54c6rN53us3v_9J5Vt98vf66u6vXNj-vVt3VtWMOnuus0gc5QbBoumZTCUGYxt5Y7SQGMBsCMSkassLbjZgvctlzD1nYFFLI5q74uuuO8HZw15aikezUmP-h0UFF79Xcn-L3axXslGGlI0xSBz08CKf6aXZ7U4LNxfa-DK14VwZwS2racF_TTP-hdnFMo9o5Uw0ByBoWChTIp5pxc93IMYHXMUC0ZqpKhOmaoHsrMxz9dvEw8h1YAsgC5tMLOpd-r_6_6CGwOqew</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Matsuo, Koji</creator><creator>Takazawa, Yutaka</creator><creator>Ross, Malcolm S.</creator><creator>Elishaev, Esther</creator><creator>Yunokawa, Mayu</creator><creator>Sheridan, Todd B.</creator><creator>Bush, Stephen H.</creator><creator>Klobocista, Merieme M.</creator><creator>Blake, Erin A.</creator><creator>Takano, Tadao</creator><creator>Baba, Tsukasa</creator><creator>Satoh, Shinya</creator><creator>Shida, Masako</creator><creator>Ikeda, Yuji</creator><creator>Adachi, Sosuke</creator><creator>Yokoyama, Takuhei</creator><creator>Takekuma, Munetaka</creator><creator>Yanai, Shiori</creator><creator>Takeuchi, Satoshi</creator><creator>Nishimura, Masato</creator><creator>Iwasaki, Keita</creator><creator>Johnson, Marian S.</creator><creator>Yoshida, Masayuki</creator><creator>Hakam, Ardeshir</creator><creator>Machida, Hiroko</creator><creator>Mhawech-Fauceglia, Paulette</creator><creator>Ueda, Yutaka</creator><creator>Yoshino, Kiyoshi</creator><creator>Kajiwara, Hiroshi</creator><creator>Hasegawa, Kosei</creator><creator>Yasuda, Masanori</creator><creator>Miyake, Takahito M.</creator><creator>Moriya, Takuya</creator><creator>Yuba, Yoshiaki</creator><creator>Morgan, Terry</creator><creator>Fukagawa, Tomoyuki</creator><creator>Pejovic, Tanja</creator><creator>Nagano, Tadayoshi</creator><creator>Sasaki, Takeshi</creator><creator>Richmond, Abby M.</creator><creator>Post, Miriam D.</creator><creator>Shahzad, Mian M. K.</creator><creator>Im, Dwight D.</creator><creator>Yoshida, Hiroshi</creator><creator>Enomoto, Takayuki</creator><creator>Omatsu, Kohei</creator><creator>Ueland, Frederick R.</creator><creator>Kelley, Joseph L.</creator><creator>Karabakhtsian, Rouzan G.</creator><creator>Roman, Lynda D.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180901</creationdate><title>Significance of Lymphovascular Space Invasion by the Sarcomatous Component in Uterine Carcinosarcoma</title><author>Matsuo, Koji ; Takazawa, Yutaka ; Ross, Malcolm S. ; Elishaev, Esther ; Yunokawa, Mayu ; Sheridan, Todd B. ; Bush, Stephen H. ; Klobocista, Merieme M. ; Blake, Erin A. ; Takano, Tadao ; Baba, Tsukasa ; Satoh, Shinya ; Shida, Masako ; Ikeda, Yuji ; Adachi, Sosuke ; Yokoyama, Takuhei ; Takekuma, Munetaka ; Yanai, Shiori ; Takeuchi, Satoshi ; Nishimura, Masato ; Iwasaki, Keita ; Johnson, Marian S. ; Yoshida, Masayuki ; Hakam, Ardeshir ; Machida, Hiroko ; Mhawech-Fauceglia, Paulette ; Ueda, Yutaka ; Yoshino, Kiyoshi ; Kajiwara, Hiroshi ; Hasegawa, Kosei ; Yasuda, Masanori ; Miyake, Takahito M. ; Moriya, Takuya ; Yuba, Yoshiaki ; Morgan, Terry ; Fukagawa, Tomoyuki ; Pejovic, Tanja ; Nagano, Tadayoshi ; Sasaki, Takeshi ; Richmond, Abby M. ; Post, Miriam D. ; Shahzad, Mian M. K. ; Im, Dwight D. ; Yoshida, Hiroshi ; Enomoto, Takayuki ; Omatsu, Kohei ; Ueland, Frederick R. ; Kelley, Joseph L. ; Karabakhtsian, Rouzan G. ; Roman, Lynda D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-ffa21fc40c3685887c45d06dd6e8411ca11054852d7ddf6cb16d96a1bdf45d783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Blood Vessels - pathology</topic><topic>Carcinosarcoma - pathology</topic><topic>Carcinosarcoma - therapy</topic><topic>Chemotherapy, Adjuvant</topic><topic>Disease Progression</topic><topic>Dominance</topic><topic>Female</topic><topic>Gynecologic Oncology</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Lymphatic Metastasis</topic><topic>Lymphatic Vessels - pathology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Neoplasm Invasiveness</topic><topic>Oncology</topic><topic>Progression-Free Survival</topic><topic>Radiation therapy</topic><topic>Radiotherapy, Adjuvant</topic><topic>Retrospective Studies</topic><topic>Sarcoma</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival</topic><topic>Survival Rate</topic><topic>Tumors</topic><topic>Uterine Neoplasms - pathology</topic><topic>Uterine Neoplasms - therapy</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsuo, Koji</creatorcontrib><creatorcontrib>Takazawa, Yutaka</creatorcontrib><creatorcontrib>Ross, Malcolm S.</creatorcontrib><creatorcontrib>Elishaev, Esther</creatorcontrib><creatorcontrib>Yunokawa, Mayu</creatorcontrib><creatorcontrib>Sheridan, Todd B.</creatorcontrib><creatorcontrib>Bush, Stephen H.</creatorcontrib><creatorcontrib>Klobocista, Merieme M.</creatorcontrib><creatorcontrib>Blake, Erin A.</creatorcontrib><creatorcontrib>Takano, Tadao</creatorcontrib><creatorcontrib>Baba, Tsukasa</creatorcontrib><creatorcontrib>Satoh, Shinya</creatorcontrib><creatorcontrib>Shida, Masako</creatorcontrib><creatorcontrib>Ikeda, Yuji</creatorcontrib><creatorcontrib>Adachi, Sosuke</creatorcontrib><creatorcontrib>Yokoyama, Takuhei</creatorcontrib><creatorcontrib>Takekuma, Munetaka</creatorcontrib><creatorcontrib>Yanai, Shiori</creatorcontrib><creatorcontrib>Takeuchi, Satoshi</creatorcontrib><creatorcontrib>Nishimura, Masato</creatorcontrib><creatorcontrib>Iwasaki, Keita</creatorcontrib><creatorcontrib>Johnson, Marian S.</creatorcontrib><creatorcontrib>Yoshida, Masayuki</creatorcontrib><creatorcontrib>Hakam, Ardeshir</creatorcontrib><creatorcontrib>Machida, Hiroko</creatorcontrib><creatorcontrib>Mhawech-Fauceglia, Paulette</creatorcontrib><creatorcontrib>Ueda, Yutaka</creatorcontrib><creatorcontrib>Yoshino, Kiyoshi</creatorcontrib><creatorcontrib>Kajiwara, Hiroshi</creatorcontrib><creatorcontrib>Hasegawa, Kosei</creatorcontrib><creatorcontrib>Yasuda, Masanori</creatorcontrib><creatorcontrib>Miyake, Takahito M.</creatorcontrib><creatorcontrib>Moriya, Takuya</creatorcontrib><creatorcontrib>Yuba, Yoshiaki</creatorcontrib><creatorcontrib>Morgan, Terry</creatorcontrib><creatorcontrib>Fukagawa, Tomoyuki</creatorcontrib><creatorcontrib>Pejovic, Tanja</creatorcontrib><creatorcontrib>Nagano, Tadayoshi</creatorcontrib><creatorcontrib>Sasaki, Takeshi</creatorcontrib><creatorcontrib>Richmond, Abby M.</creatorcontrib><creatorcontrib>Post, Miriam D.</creatorcontrib><creatorcontrib>Shahzad, Mian M. K.</creatorcontrib><creatorcontrib>Im, Dwight D.</creatorcontrib><creatorcontrib>Yoshida, Hiroshi</creatorcontrib><creatorcontrib>Enomoto, Takayuki</creatorcontrib><creatorcontrib>Omatsu, Kohei</creatorcontrib><creatorcontrib>Ueland, Frederick R.</creatorcontrib><creatorcontrib>Kelley, Joseph L.</creatorcontrib><creatorcontrib>Karabakhtsian, Rouzan G.</creatorcontrib><creatorcontrib>Roman, Lynda D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsuo, Koji</au><au>Takazawa, Yutaka</au><au>Ross, Malcolm S.</au><au>Elishaev, Esther</au><au>Yunokawa, Mayu</au><au>Sheridan, Todd B.</au><au>Bush, Stephen H.</au><au>Klobocista, Merieme M.</au><au>Blake, Erin A.</au><au>Takano, Tadao</au><au>Baba, Tsukasa</au><au>Satoh, Shinya</au><au>Shida, Masako</au><au>Ikeda, Yuji</au><au>Adachi, Sosuke</au><au>Yokoyama, Takuhei</au><au>Takekuma, Munetaka</au><au>Yanai, Shiori</au><au>Takeuchi, Satoshi</au><au>Nishimura, Masato</au><au>Iwasaki, Keita</au><au>Johnson, Marian S.</au><au>Yoshida, Masayuki</au><au>Hakam, Ardeshir</au><au>Machida, Hiroko</au><au>Mhawech-Fauceglia, Paulette</au><au>Ueda, Yutaka</au><au>Yoshino, Kiyoshi</au><au>Kajiwara, Hiroshi</au><au>Hasegawa, Kosei</au><au>Yasuda, Masanori</au><au>Miyake, Takahito M.</au><au>Moriya, Takuya</au><au>Yuba, Yoshiaki</au><au>Morgan, Terry</au><au>Fukagawa, Tomoyuki</au><au>Pejovic, Tanja</au><au>Nagano, Tadayoshi</au><au>Sasaki, Takeshi</au><au>Richmond, Abby M.</au><au>Post, Miriam D.</au><au>Shahzad, Mian M. K.</au><au>Im, Dwight D.</au><au>Yoshida, Hiroshi</au><au>Enomoto, Takayuki</au><au>Omatsu, Kohei</au><au>Ueland, Frederick R.</au><au>Kelley, Joseph L.</au><au>Karabakhtsian, Rouzan G.</au><au>Roman, Lynda D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of Lymphovascular Space Invasion by the Sarcomatous Component in Uterine Carcinosarcoma</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>25</volume><issue>9</issue><spage>2756</spage><epage>2766</epage><pages>2756-2766</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Objective
The aim of this study was to examine the significance of lymphovascular space invasion (LVSI) with a sarcomatous component on the tumor characteristics and clinical outcomes of women with uterine carcinosarcoma (UCS).
Methods
This was a secondary analysis of a prior multicenter retrospective study that examined women with stage I–IV UCS who underwent primary hysterectomy. Archived histopathology slides were reviewed and LVSI was scored as follows: LVSI with a carcinomatous component alone (LVSI-carcinoma;
n
= 375, 76.8%) or LVSI containing a sarcomatous component with or without a carcinomatous component (LVSI-sarcoma;
n
= 113, 23.2%). Qualitative metrics of LVSI were correlated to clinicopathological factors and survival outcome.
Results
Tumors in the LVSI-sarcoma group were more likely to have sarcoma dominance (82.1 vs. 26.4%) heterologous sarcomatous component (51.3 vs. 37.9%), low-grade carcinoma (42.5 vs. 22.4%), and large tumor size (81.0 vs. 70.2%) in the primary tumor site compared with tumors in the LVSI-carcinoma group (all
p
< 0.05). On multivariate analysis, LVSI-sarcoma was independently associated with decreased progression-free survival (5-year rates: 34.9 vs. 40.8%, adjusted hazard ratio [HR] 1.84, 95% confidence interval [CI] 1.36–2.50,
p
< 0.001), and cause-specific survival (5-year rates: 41.8 vs. 55.9%, adjusted HR 1.95, 95% CI 1.39–2.75,
p
< 0.001) compared with LVSI-carcinoma. Postoperative radiotherapy for women with LVSI-sarcoma had a higher reduction rate of recurrence/progression of disease (54% reduction,
p
= 0.04) compared with postoperative radiotherapy for women with LVSI-carcinoma (26% reduction,
p
= 0.08).
Conclusion
In UCS, the presence of a sarcomatous component in LVSI is particularly prevalent when a tumor has sarcoma dominance. Our study suggests that LVSI containing a sarcomatous component may be a predictor of decreased survival for women with UCS.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>29971677</pmid><doi>10.1245/s10434-018-6547-x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2018-09, Vol.25 (9), p.2756-2766 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7523233 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Blood Vessels - pathology Carcinosarcoma - pathology Carcinosarcoma - therapy Chemotherapy, Adjuvant Disease Progression Dominance Female Gynecologic Oncology Humans Hysterectomy Lymphatic Metastasis Lymphatic Vessels - pathology Medicine Medicine & Public Health Middle Aged Multivariate analysis Neoplasm Invasiveness Oncology Progression-Free Survival Radiation therapy Radiotherapy, Adjuvant Retrospective Studies Sarcoma Surgery Surgical Oncology Survival Survival Rate Tumors Uterine Neoplasms - pathology Uterine Neoplasms - therapy Uterus |
| title | Significance of Lymphovascular Space Invasion by the Sarcomatous Component in Uterine Carcinosarcoma |
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