Significance of Lymphovascular Space Invasion by the Sarcomatous Component in Uterine Carcinosarcoma
Objective The aim of this study was to examine the significance of lymphovascular space invasion (LVSI) with a sarcomatous component on the tumor characteristics and clinical outcomes of women with uterine carcinosarcoma (UCS). Methods This was a secondary analysis of a prior multicenter retrospecti...
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Veröffentlicht in: | Annals of surgical oncology 2018-09, Vol.25 (9), p.2756-2766 |
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Sprache: | eng |
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Zusammenfassung: | Objective
The aim of this study was to examine the significance of lymphovascular space invasion (LVSI) with a sarcomatous component on the tumor characteristics and clinical outcomes of women with uterine carcinosarcoma (UCS).
Methods
This was a secondary analysis of a prior multicenter retrospective study that examined women with stage I–IV UCS who underwent primary hysterectomy. Archived histopathology slides were reviewed and LVSI was scored as follows: LVSI with a carcinomatous component alone (LVSI-carcinoma;
n
= 375, 76.8%) or LVSI containing a sarcomatous component with or without a carcinomatous component (LVSI-sarcoma;
n
= 113, 23.2%). Qualitative metrics of LVSI were correlated to clinicopathological factors and survival outcome.
Results
Tumors in the LVSI-sarcoma group were more likely to have sarcoma dominance (82.1 vs. 26.4%) heterologous sarcomatous component (51.3 vs. 37.9%), low-grade carcinoma (42.5 vs. 22.4%), and large tumor size (81.0 vs. 70.2%) in the primary tumor site compared with tumors in the LVSI-carcinoma group (all
p
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ISSN: | 1068-9265 1534-4681 |
DOI: | 10.1245/s10434-018-6547-x |