Significance of Lymphovascular Space Invasion by the Sarcomatous Component in Uterine Carcinosarcoma

Objective The aim of this study was to examine the significance of lymphovascular space invasion (LVSI) with a sarcomatous component on the tumor characteristics and clinical outcomes of women with uterine carcinosarcoma (UCS). Methods This was a secondary analysis of a prior multicenter retrospecti...

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Veröffentlicht in:Annals of surgical oncology 2018-09, Vol.25 (9), p.2756-2766
Hauptverfasser: Matsuo, Koji, Takazawa, Yutaka, Ross, Malcolm S., Elishaev, Esther, Yunokawa, Mayu, Sheridan, Todd B., Bush, Stephen H., Klobocista, Merieme M., Blake, Erin A., Takano, Tadao, Baba, Tsukasa, Satoh, Shinya, Shida, Masako, Ikeda, Yuji, Adachi, Sosuke, Yokoyama, Takuhei, Takekuma, Munetaka, Yanai, Shiori, Takeuchi, Satoshi, Nishimura, Masato, Iwasaki, Keita, Johnson, Marian S., Yoshida, Masayuki, Hakam, Ardeshir, Machida, Hiroko, Mhawech-Fauceglia, Paulette, Ueda, Yutaka, Yoshino, Kiyoshi, Kajiwara, Hiroshi, Hasegawa, Kosei, Yasuda, Masanori, Miyake, Takahito M., Moriya, Takuya, Yuba, Yoshiaki, Morgan, Terry, Fukagawa, Tomoyuki, Pejovic, Tanja, Nagano, Tadayoshi, Sasaki, Takeshi, Richmond, Abby M., Post, Miriam D., Shahzad, Mian M. K., Im, Dwight D., Yoshida, Hiroshi, Enomoto, Takayuki, Omatsu, Kohei, Ueland, Frederick R., Kelley, Joseph L., Karabakhtsian, Rouzan G., Roman, Lynda D.
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Sprache:eng
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Zusammenfassung:Objective The aim of this study was to examine the significance of lymphovascular space invasion (LVSI) with a sarcomatous component on the tumor characteristics and clinical outcomes of women with uterine carcinosarcoma (UCS). Methods This was a secondary analysis of a prior multicenter retrospective study that examined women with stage I–IV UCS who underwent primary hysterectomy. Archived histopathology slides were reviewed and LVSI was scored as follows: LVSI with a carcinomatous component alone (LVSI-carcinoma; n  = 375, 76.8%) or LVSI containing a sarcomatous component with or without a carcinomatous component (LVSI-sarcoma; n  = 113, 23.2%). Qualitative metrics of LVSI were correlated to clinicopathological factors and survival outcome. Results Tumors in the LVSI-sarcoma group were more likely to have sarcoma dominance (82.1 vs. 26.4%) heterologous sarcomatous component (51.3 vs. 37.9%), low-grade carcinoma (42.5 vs. 22.4%), and large tumor size (81.0 vs. 70.2%) in the primary tumor site compared with tumors in the LVSI-carcinoma group (all p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-018-6547-x