UV-LED disinfection of Coronavirus: Wavelength effect

UV light-emitting diodes (UV LEDs) are an emerging technology and a UV source for pathogen inactivation, however low UV-LED wavelengths are costly and have low fluence rate. Our results suggest that the sensitivity of human Coronavirus (HCoV-OC43 used as SARS-CoV-2 surrogate) was wavelength dependen...

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Veröffentlicht in:	Journal of photochemistry and photobiology. B, Biology Biology, 2020-11, Vol.212, p.112044-112044, Article 112044
Hauptverfasser:	Gerchman, Yoram, Mamane, Hadas, Friedman, Nehemya, Mandelboim, Michal
Format:	Artikel
Sprache:	eng
Schlagworte:	Betacoronavirus - genetics Betacoronavirus - isolation & purification Betacoronavirus - radiation effects Corona Coronavirus Coronavirus Infections - pathology Coronavirus Infections - virology Coronaviruses COVID-19 COVID19 Deactivation Disinfection Fluence Humans Inactivation Light emitting diodes New technology Pandemics Pneumonia, Viral - pathology Pneumonia, Viral - virology Radiation Dosage Real-Time Polymerase Chain Reaction RNA, Viral - metabolism SARS SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Ultraviolet radiation Ultraviolet Rays UV-LEDs Viral diseases Virus Inactivation - radiation effects Viruses Wavelength Wavelengths
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Zusammenfassung:	UV light-emitting diodes (UV LEDs) are an emerging technology and a UV source for pathogen inactivation, however low UV-LED wavelengths are costly and have low fluence rate. Our results suggest that the sensitivity of human Coronavirus (HCoV-OC43 used as SARS-CoV-2 surrogate) was wavelength dependent with 267 nm ~ 279 nm > 286 nm > 297 nm. Other viruses showed similar results, suggesting UV LED with peak emission at ~286 nm could serve as an effective tool in the fight against human Coronaviruses. [Display omitted] •Corona virus HCoV-43 was found sensitive to UV-LED irradiation.•Sensitivity was wavelength dependent with 267 nm ~ 279 nm > 286 nm > 297 nm.•Similar wavelength sensitivity was found for other viruses.•UV-LEDs could probably be used in the fight against SARS-CoV-2 and COVID19.
ISSN:	1011-1344 1873-2682
DOI:	10.1016/j.jphotobiol.2020.112044